Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity

Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis.

Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts.

Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase.

The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones.

The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis.

Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations.