Biopsy Interpretation of the Lymph Node

Description:

A new volume in the highly regarded Biopsy Interpretation Series, Biopsy Interpretation of the Lymph Node provides concise, abundantly illustrated information on the pathologic approach to diagnosis for these frequently encountered biopsies. Practical and well organized, this highly readable volume edited by Drs. Rebecca L. King, Anamarija M. Perry, and Lauren B. Smith, addresses both common and unusual issues that arise in the day-to-day interpretation of non-neoplastic and neoplastic lymph node biopsies, teaching the best diagnostic practices as well as how to avoid the most common pitfalls. Focusing on the daily tasks and needs of the general pathologist, it provides a solid foundation for clinical diagnostic decision making.

Table of Contents

1. Lymph Node Evaluation

Pattern-based Approach to Lymph Node Evaluation

Normal Lymph Node Histology

Cortex

Paracortex

Medulla

Small/Needle Core Biopsy Evaluation—Challenges and Pitfalls

Nonhematopoietic Entities Mimicking Lymphoma

Small Round Blue Cell Tumors

Tumors With Plasmacytoid Morphology

Tumors and Nonneoplastic Conditions With Prominent Sclerosis and Inflammation (“Sclerotic Pattern”)

Tumors With Epithelioid or Anaplastic Morphology

2. Diagnostic Methods and Ancillary Studies

Processing of the Lymph Node Biopsy Specimen

Special Stains

Immunohistochemistry

Flow Cytometric Analysis

FISH and Other Cytogenetic Analyses

Small B-cell Lymphomas

Large/High-grade B-cell Lymphomas

T-cell Lymphomas

Molecular Analysis

Infectious Agents

Immunoglobulin/T-cell Receptor Gene Rearrangements

Lymphoid Next-generation Sequencing Assays

3. Benign Diseases Involving Lymph Node

Follicular and Paracortical Hyperplasia

Sinus Histiocytosis

Progressive Transformation of Germinal Centers

Viral Lymphadenitis

Epstein-Barr Virus Lymphadenitis (Infectious Mononucleosis)

Cytomegalovirus Lymphadenitis

Herpes Simplex Virus Lymphadenitis

Human Immunodeficiency Virus Lymphadenitis

Bacterial Lymphadenitis

Cat-scratch Disease and Other Causes of Suppurative Lymphadenitis

Bacillary Angiomatosis

Syphilitic (Luetic) Lymphadenitis

Mycobacterial Lymphadenitis (Mycobacterium tuberculosis and Nontuberculous Mycobacteria)

Fungal Lymphadenitis

Histoplasma Lymphadenitis

Coccidiomycosis Lymphadenitis

Protozoal Lymphadenitis

Toxoplasma Lymphadenitis

Histiocytic Necrotizing Lymphadenitis (Kikuchi-Fujimoto Disease)

Sarcoidosis Lymphadenopathy

Autoimmune Lymphadenopathy

Rheumatoid Arthritis

Systemic Lupus Erythematosus

Castleman Disease

Dermatopathic Lymphadenopathy

Kimura Lymphadenopathy

IgG4-RELATED LYMPHADENOPATHY

Drug-induced Lymphadenopathy

Vascular Transformation of Sinuses

4. Precursor Lymphoid Neoplasms, Myeloid Sarcoma, and Blastic Plasmacytoid Dendritic Cell Neoplasm

B-lymphoblastic Leukemia/Lymphoma

Morphology

Phenotype

Genetics

T-lymphoblastic Leukemia/Lymphoma

Morphology

Phenotype

Genetics

Myeloid Sarcoma

Morphology

Phenotype

Genetics

Blastic Plasmacytoid Dendritic Cell Neoplasm

Morphology

Phenotype

Genetics

5. Mature B-cell Neoplasms

Small B-cell Lymphoma

Follicular Lymphoma

Morphology

Phenotype

Genetics

Pediatric-type FL

In Situ Follicular Neoplasia

Nodal Marginal Zone Lymphoma

Morphology

Phenotype

Genetics

Pediatric NMZL

Mantle Cell Lymphoma

Morphology

Phenotype

Genetics

In Situ Mantle Cell Neoplasia

Lymphoplasmacytic Lymphoma

Morphology

Phenotype

Genetics

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Morphology

Phenotype

Genetics

Other Small B-cell Neoplasms Involving Lymph Nodes

Large and High-grade B-cell Lymphoma

Diffuse Large B-cell Lymphoma, not Otherwise Specified

Morphology

Phenotype

Cell of Origin

Dual Expression of BCL2 and MYC by IHC

Genetics

Subtypes of DLBCL

T-cell/Histiocyte-rich Large B-cell Lymphoma

Morphology

Phenotype

Genetics

EBV-positive DLBCL, NOS

Morphology

Phenotype

Genetics

Primary Mediastinal (Thymic) Large B-cell Lymphoma

Morphology

Phenotype

Genetics

ALK-positive Large B-cell Lymphoma

Morphology

Phenotype

Genetics

Plasmablastic Lymphoma

Morphology/Phenotype

Genetics

HHV8-associated Lymphoproliferative Disorders

HHV8-positive Multicentric Castleman Disease

HHV8-positive DLBCL, NOS

HHV8-positive Germinotropic Lymphoproliferative Disorder

Burkitt Lymphoma

Epidemiological Variants of BL

Morphology

Phenotype

Genetics

Large B-cell Lymphoma With 11q Aberration

High-grade B-cell Lymphoma With MYC and BCL2 Rearrangements and High-grade B-cell Lymphoma With MYC and BCL6 Rearrangements

Morphology

Phenotype

Genetics

High-grade B-cell lymphoma, NOS

Mediastinal Gray Zone Lymphoma

Morphology

Phenotype

Genetics

6. Mature T-Cell Neoplasms

Peripheral T-cell Lymphoma, Not Otherwise Specified

Morphology

Phenotype

Genetics

Follicular Helper T-cell Lymphomas

Angioimmunoblastic T-cell Lymphoma

Follicular Helper T-cell Lymphoma, Follicular Type

Follicular Helper T-cell Lymphoma, NOS

Anaplastic Large-cell Lymphoma, ALK-positive

Morphology

Phenotype

Genetics

Anaplastic Large-cell Lymphoma, ALK-Negative

Morphology

Phenotype

Genetics

Other T-cell Lymphomas That Can Involve Lymph Nodes

T-cell Prolymphocytic Leukemia

Adult T-cell Leukemia/Lymphoma

Mycosis Fungoides and Sézary Syndrome

7. Classic Hodgkin Lymphoma and Nodular Lymphocyte Predominant B-Cell Lymphoma

Classic Hodgkin Lymphoma

Morphology

Phenotype

Genetics

Nodular Lymphocyte-predominant B-cell Lymphoma

Morphology

Phenotype

Genetics

8. Lymphoproliferative Disorders Associated With Immunodeficiency

Posttransplant Lymphoproliferative Disorders

Morphologic Subtypes of PTLD

Genetics

Lymphoproliferative Disorders Associated With Primary Immunodeficiency Disorders

Morphology

Iatrogenic Lymphoproliferative Disorders

Lymphomas Associated With HIV Infection

9. Histiocytic and Dendritic Cell Neoplasms

Rosai-Dorfman Disease

Morphology

Phenotype

Genetics

Histiocytic Sarcoma

Morphology

Phenotype

Genetics

Follicular Dendritic Cell Sarcoma

Morphology

Phenotype

Genetics

Interdigitating Dendritic Cell Sarcoma

Morphology

Phenotype

Genetics

Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma

Morphology

Phenotype

Genetics

Appendix 1

Index

Review Questions