Cardiovascular Genetics and Genomics: Principles and Clinical Practice

Description:

This title reflects the exponential growth in the knowledge and information on this subject and defines the extensive clinical translation of cardiovascular genetics and genomics in clinical practice. This concise, clinically oriented text is targeted at a broad range of clinicians who manage patients and families with a wide range of heterogeneous inherited cardiovascular conditions. Cardiovascular Genetics and Genomics: Principles and Clinical Practice includes a concise and clear account on selected topics written by a team of leading experts on clinical cardiovascular genetics. Each chapter include key information to assist the clinician and case histories have been incorporated to reflect contemporary practice in clinical cardiovascular genetics and genomics. Therefore this will be of key importance to all professionals working in the discipline, from clinicians and trainees in cardiology, cardiac surgery, electrophysiology, immunology through geneticists, nursing staff and those involved in precision medicine.

Table of contents:

1. Introduction to Genes, Genome and Inheritance

2. Spectrum and Classification of Inherited Cardiovascular Disease

3. Principles and Practice of Genetic Counselling for Inherited Cardiac Conditions

4. Genetic and Genomic Technologies: Next Generation Sequencing for Inherited Cardiovascular Conditions

5. Pharmacogenetics and Pharmacogenomics in Cardiovascular Medicine and Surgery

6. Congenital Cardiovascular Disorders

7. Inherited Cardiovascular Metabolic Disorders

8. Mitochondrial Cardiovascular Diseases

9. Inherited Cardiac Muscle Disorders: Hypertrophic and Restrictive Cardiomyopathies

10. Inherited Cardiac Muscle Disease: Dilated Cardiomyopathy

11. Inherited Cardiac Muscle Disorders: Arrhythmogenic Right Ventricular Cardiomyopathy

12. Inherited Cardiac Muscle Disorders: Left Ventricular Noncompaction

13. Inherited Arrhythmias: LQTS/SQTS/CPVT

14. Inherited Arrhythmias: Brugada Syndrome and Early Repolarisation Syndrome

15. Inherited Conduction Disease and Atrial Fibrillation

16. Cardiovascular Manifestations in Duchenne/Becker Muscular Dystrophy and Other Primary Myopathies

17. Familial Cardiac Amyloidoses

18. Cardiovascular Manifestations of Myotonic Dystrophy

19. Marfan Syndrome and Related Disorders

20. Cardiovascular Manifestations in Inherited Connective Tissue Disorders

21. Thoracic Aortic Dilatation, Aneurysm and Dissection

22. Genetics and Genomics of Coronary Artery Disease

23. Cardiovascular Manifestations of Immune-Mediated Inflammatory Disorders

24. Genetics and Genomics of Stroke

25. Genetics and Genomics of Systemic Hypertension

26. Inherited Pulmonary Arterial Hypertension

27. Genetics and Genomics of Sudden Unexplained Cardiac Death

28. Specific Issues in Clinical Genetics and Genetic Counselling Practices Related to Inherited Cardiovascular Conditions

29. Multi-Disciplinary Management of Inherited Cardiovascular Conditions

30. Interventions and Implantable Devices for Inherited Cardiac Conditions

31. Inherited Cardiovascular Conditions: Phenotype-Genotype Data Mining and Sharing, and Databases

Back Matter