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DESCRIPTION
Clinical Pancreatology
Since the book?Clinical Pancreatology for Practising Gastroenterologists and Surgeons?was first published sixteen years ago, the knowledge and clinical management of pancreatic diseases have developed markedly. Thanks to the development of the translational research and the?from bench to bedside?concept, much progress from the lab has been applied to clinical practice. In addition, several highly relevant clinical trials published over the last years have resulted in the update and optimisation of clinical guidelines.
A new and validated classification of severity and complications of acute pancreatitis is firmly rooted in clinical practice and has been the basis for the development of minimally invasive approaches to pancreatic necrosis. The etiopathogenic knowledge of chronic pancreatitis and other pancreatopaties, like that associated with diabetes mellitus, has developed significantly. Especially important has been the development of the field of cystic pancreatic tumours, which has been reflected in the publication of several guidelines and consensus reports over the last few years. Most research efforts have focused on pancreatic cancer, which have led and will further lead to a significant increase in the therapeutic armamentarium against this devastating disease. Finally, many newly published studies have changed the concept, causes, clinical relevance, diagnosis and treatment of exocrine pancreatic insufficiency.
This new edition of?Clinical Pancreatology for Practising Gastroenterologists and Surgeons?has enjoyed the collaboration of the world?s leading experts in each of the areas of clinical pancreatology with the aim of facilitating gastroenterologists, surgeons, oncologists, internists, nutritionists, diabetologists, paediatricians, radiologists, pathologists and other specialists in their decision making when facing patients with pancreatic diseases in their daily clinical practice. All in all, this book supplies an indispensable update of the relevant aspects of clinical pancreatology.
ABOUT THE AUTHOR
About the editor
Prof.?J. Enrique Dom?nguez-Mu?oz?graduated in medicine from the University of Alcal? de Henares in Madrid, and got his PhD at the same University in
1990. In 1998, he became Director of the Department of Gastroenterology and Hepatology at the University Hospital of Santiago de Compostela, Spain. He is also Professor of Medicine at the University of Santiago de Compostela and permanent member of the Royal Academy of Medicine of Galicia. He has published more than 300 papers in peer reviewed journals, and has edited 12 books. He has been elected President of the European Pancreatic Club for
2024.
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TABLE OF CONTENTS
Contributors
Foreword
Preface
Dedication
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1 Acute pancreatitis: An overview
Jodie A. Barkin, Jamie S. Barkin
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2 How to deal with the etiological diagnosis of acute pancreatitis in clinical practice
Soumya Jagannath, Pramod Kumar Garg
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3 Definition of Complications and Severity of Acute Pancreatitis for Clinical Practice
David X. Jin, Peter A. Banks, Julia McNabb-Baltar
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4 Early prediction of severity in acute pancreatitis: What can be done in clinical practice?
Peter J Lee, Georgios I Papachristou
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5 Role of CT Scan in Acute Pancreatitis: When is it Indicated and What Information can be Obtained?
Elham Afghani, Mahya Faghih, Vikesh Singh
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6 Role of MRI in acute pancreatitis. When is it indicated and what information can be obtained?
Fatih Akisik
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7 Treatment of acute pancreatitis in the emergency room: What should be done during the first hours of disease?
Thiruvengadam Muniraj and Santhi Swaroop Vege
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8 Acute pancreatitis: A practical guideline for the monitoring and treatment of systemic complications
Enrique de-Madaria and Felix Zubia-Olaskoaga
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9 Guidelines for the treatment of pain in acute pancreatitis
L?szl? Czak?
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10 Nutrition in the acute phase of pancreatitis: Why, when, how and how long?
Angela Pham and Chris E Forsmark
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11 Oral refeeding in acute pancreatitis: When and how should it be restarted?
Jos? Lari?o-Noia, Daniel de la Iglesia-Garc?a
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12 Pharmacological therapy for acute pancreatitis: any light at the end of the tunnel?
Rajarshi Mukherjee, Muhammad Awais, Wenhao Cai, Wei Huang, Peter Szatmary, Robert Sutton
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13 Indication and optimal timing of ERCP in acute pancreatitis
Theodor Voiosu, Ivo Bo?koski, Guido Costamagna
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14 How to deal with infected pancreatic necrosis?
J. Enrique Dom?nguez Mu?oz
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15. Minimally invasive surgical necrosectomy in clinical practice: Indications, technical issues and optimal timing.
Patricia S?nchez-Vel?zquez, Fernando Burd?o, Ignasi Poves
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16 Endoscopic Necrosectomy in Clinical Practice: Indications, Technical issues and Optimal Timing
Jodie A Barkin, and Andres Gelrud
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17 MANAGEMENT OF ACUTE PANCREATIC PSEUDOCYST: WHEN TO OBSERVE, WHEN AND HOW TO DRAIN
Muhammad F. Dawwas, Kofi W. Oppong
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18 The disconnected main pancreatic duct syndrome: How to proceed with it in clinical practice?
Mario Pel?ez-Luna, Andrea Soriano-R?os, Luis Uscanga-Dominguez
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19 Vasculature Complications in Pancreatitis: How to Deal with Them?
Daniel G. McCall and Timothy B. Gardner
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20 Acute relapsing pancreatitis: What can be done to prevent relapses?
Jorge D. Machicado, Dhiraj Yadav
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21 Diagnosis and therapeutic approach to pancreatic exocrine insufficiency after acute pancreatitis
H.C. Timmerhuis, C. J. Sperna Weiland, H.C. van Santvoort
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22 Asymptomatic chronic elevation of serum pancreatic enzymes: How to deal with it?
Giuseppe Vanella, Paolo Giorgio Arcidiacono, Gabriele Capurso
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23 Definition and etiology of chronic pancreatitis: What is relevant for clinical practice?
David C. Whitcomb
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24 Epidemiology of chronic pancreatitis: An infrequent disease or an infrequently diagnosed disease?
Philippe L?vy, Vinciane Rebours
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25 Alcoholic chronic pancreatitis and the impact of alcohol and smoking cessation in chronic pancreatitis
JS Wilson, RC Pirola, MV Apte
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26 What is relevant on genetics in chronic pancreatitis for clinical practice? What genes and when to evaluate them?
Jonas Rosendahl
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27 Pancreas divisum and other potential obstructive causes of chronic pancreatitis (When and how to treat them?)
Matthew J. DiMagno, Erik-Jan Wamsteker
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28 What to do in clinical practice before defining a chronic pancreatitis as idiopathic? A practical protocol
Felix L?mmerhirt, Frank Ulrich Weiss, Markus M. Lerch
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29 CT for the diagnosis, evaluation of severity and detection of complications of chronic pancreatitis in clinical practice
Roberto Garc?a-Figueiras, Sandra Baleato-Gonz?lez, Gonzalo Tard?guila de la Fuente
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30 Role of MRI and MRCP for the diagnosis, evaluation of severity and detection of complications of chronic pancreatitis in clinical practice.
Jordan K. Swensson, Temel Tirkes
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31 Role of endoscopic ultrasound and associated methods (elastography, contrast enhancement) for the diagnosis, evaluation of severity and detection of complications of chronic pancreatitis in clinical practice.
Julio Iglesias-Garcia
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32 Endoscopic pancreatic function test for the functional diagnosis of chronic pancreatitis: indications and practical protocol
Luis F. Lara, Darwin L. Conwell
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33 Role of pancreatic function tests for the diagnosis of chronic pancreatitis: Which tests and how should they be performed in clinical practice?
J. Enrique Dom?nguez Mu?oz
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34 Follow-up of patients with chronic pancreatitis in clinical practice: How and what for?
Antonio Mendoza Ladd, Luis F. Lara, Darwin L. Conwell
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35 QUALITY OF LIFE IN CHRONIC PANCREATITIS
Colin D Johnson
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36 Medical treatment of pain in chronic pancreatitis:? Guidelines for clinical practice
Asbj?rn Mohr Drewes, Louise Kuhlman, Trine Andresen & S?ren Schou Olesen
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37 Endoscopic treatment of pain in chronic pancreatitis:
Indications, optimal timing and technical aspects
P.M.C. Stassen, P.J.F. de Jonge, J.W. Poley, D.L. Cahen, M.J. Bruno
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38? Diagnosis and management of pancreatic exocrine insufficiency in chronic pancreatitis: A practical protocol
J. Enrique Dom?nguez-Mu?oz
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39 Surgical treatment of pain in chronic pancreatitis: indications, optimal timing and technical approaches
?Benjamin PT Loveday, John A Windsor
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40 Management of chronic pancreatic pseudocyst: when to observe, when and how to drain?
Shyam Varadarajulu
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41 Vascular complications in chronic pancreatitis
Anil K Agarwal, Raja Kalayarasan, Amit Javed
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42 SURGICAL THERAPY OF LOCAL COMPLICATIONS OF CHRONIC PANCREATITIS: INDICATIONS, TECHNICAL APPROACHES AND OPTIMAL TIMING
Ricardo Arvizu Castillo, Elena Mu?oz-Forner, Luis Sabater
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43 Endoscopic treatment of complications of chronic pancreatitis other than pseudocyst
Jahangeer Basha, Rupjyoti Talukdar, D. Nageshwar Reddy.
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44 Autoimmune pancreatitis: Definition, clinical presentation and classification.
Miroslav Vujasinovic and J.-Matthias L?hr
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45 Diagnosis of Autoimmune Pancreatitis: a Protocol for Clinical Practice
Nicol? de Pretis , Antonio Amodio and Luca Frulloni
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46 Treatment and follow-up of autoimmune pancreatitis in clinical practice
Sushil Kumar Garg, Suresh T Chari
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47 CFTR-associated pancreatic disease: genotype-phenotype correlations and impact of CFTR-modifying therapy
Aimee Joy Wiseman and Chee Y. Ooi
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48: Nutritional therapy, pancreatic exocrine insufficiency, and pancreatic enzyme replacement therapy in cystic fibrosis: a protocol for clinical practice
Jefferson N. Brownell, Laura Padula, Elizabeth Reid, Virginia A. Stallings, Asim Maqbool,
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49 EPIDEMIOLOGICAL IMPACT OF PANCREATIC CANCER
Patrick Maisonneuve
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50 Molecular and genetic basis of pancreatic carcinogenesis: Which concepts are clinically relevant?
Ihsan Ekin Demir, Carmen Mota Reyes, Elke Demir, Helmut Friess
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51 New-onset diabetes as a harbinger of pancreatic cancer:
Is early diagnosis possible?
Dana K. Andersen, Suresh T. Chari, Eithne Costello, Tatjana Crnogorac-Jurcevic, Phil A. Hart, Anirban Maitra, Stephen J. Pandol
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52 Pancreatic cancer screening: Target populations, methods and protocols for clinical practice
Christopher Paiji, Anne Marie Lennon, Elham Afghani
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53 Clinical usefulness of biological markers in pancreatic cancer
David Anz, Ignazio Piseddu, Marlies K?pke, Ujjwal M. Mahajan, Julia Mayerle
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54 Staging classification and stratification of pancreatic cancer for clinical practice
Akhil Chawla and Andrew J. Aguirre, MD, PhD
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55 Imaging diagnosis and staging of pancreatic cancer: Which methods are essential and what information should they provide?
Megan H. Lee, Elliot K. Fishman
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56 THE ROLE OF ENDOSCOPIC ULTRASOUND AND ASSOCIATED METHODS (ELASTOGRAPHY, CONTRAST ENHANCEMENT) IN THE DIAGNOSIS AND ASSESSMENT OF RESECTABILITY OF PANCREATIC CANCER
M. Giovannini
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57 EUS-GUIDED FNA/FNB FOR PANCREATIC SOLID LESIONS: WHEN IS IT INDICATED AND WHAT IS THE OPTIMAL TECHNICAL APPROACH?
Mihai Rimba?, Gianenrico Rizzatti and Alberto Larghi
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58 Surgical treatment of resectable pancreatic cancer. What is the optimal strategy?
Jan G. D?Haese, Bernhard W. Renz, Jens Werner
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59 Complications after pancreatic surgery. How to deal with them.
Tommaso Giuliani, Giovanni Marchegiani, Giuseppe Malleo, Claudio Bassi
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60 Neoadjuvant treatment of pancreatic cancer: when and how?
Marta Sandini, Thilo Hackert, Ulla Klaiber, Markus W. B?chler, John P. Neoptolemos
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61 Adjuvant therapy in pancreatic cancer : options, safety and outcomes
Jean-Luc Van Laethem
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62 Management of pain in pancreatic cancer: An algorithm for clinical routine
J. Enrique Dom?nguez-Mu?oz
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63 EUS-guided celiac plexus neurolysis for pain in pancreatic cancer: when and how?
Jonathan M. Wyse, Anand V. Sahai,
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64 The role of endoscopy in the management of unresectable pancreatic cancer
Jaimin Amin, Ajaypal Singh, and Irving Waxman
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65 Chemotherapy for non-resectable pancreatic cancer
Raquel Fuentes, Juan Jos? Serrano, Mercedes Rodr?guez, Alfredo Carrato.
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66 Diagnosis and management of pancreatic exocrine insufficiency in pancreatic cancer.
Sarah Powell-Brett, Keith J Roberts
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67 Nutrition and Pancreatic Cancer
Mary Phillips, Oonagh Griffin
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68 Present and future of local therapies for unresectable pancreatic cancer
Testoni Sabrina Gloria Giulia, Rossi Gemma, Archibugi Livia, Arcidiacono Paolo Giorgio
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69 New pharmacological approaches for pancreatic cancer therapy: A light at the end of the tunnel?
Vineet K Gupta, Sulagna Banerjee and Ashok Saluja
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70 Histologic classification of pancreatic cystic neoplasms
Giuseppe Zamboni, Anna Pesci
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71 Incidental pancreatic cystic lesion: How to deal with it?
Atsushi Oba, Robert J. Torphy, Richard D. Schulick, and Marco Del Chiaro
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72 Role of endoscopic ultrasound and endoscopic ultrasound-associated techniques in the diagnosis and differential diagnosis of pancreatic cystic tumors
Mar?a-Victoria Alvarez-S?nchez and Bertrand Napol?on
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73 The role of multidetector CT, MRI and MRCP in the diagnosis and differential diagnosis of pancreatic cystic neoplasms
Megan H. Lee, Elliot K. Fishman
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74 Intraductal papillary mucinous neoplasm (IPMN): When to observe, when to operate and optimal surgical approach
Zhi Ven Fong, Carlos Fernandez-del Castillo
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75 Cystic tumours others than IPMN: When to observe, when to operate and optimal surgical approach
John W. Kunstman, James J Farrell
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76 Pancreatic cystic tumors: any role for local therapies?
Julio Iglesias-Garcia
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77. Diagnosis and treatment of pancreatic neuroendocrine tumours: how to deal with them in clinical practice
Francesca Muffatti, Stefano Partelli, Valentina Andreasi, and Massimo Falconi
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78 OTHER LESS FREQUENT PANCREATIC TUMOURS: WHAT SHOULD BE KNOWN ABOUT CLINICAL FEATURES, DIAGNOSIS AND TREATMENT?
Rossana Percario, Paolo Panaccio, Fabio F. di Mola, Pierluigi Di Sebastiano and Tommaso Grottola
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79 Diagnosis and therapy of exocrine pancreatic insufficiency after gastric and pancreatic surgery
Raffaele Pezzilli
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80 Pancreatic exocrine insufficiency in type 1 and type 2 diabetes mellitus: Lessons from pancreatologists to diabetologists
Philip D Hardt
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Chapter 81 Diabetes mellitus related to diseases of the exocrine pancreas (pancreatogenic diabetes): diagnosis and treatment.
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