Critical Care of the Solid Organ Transplant Patient, An Issue of Critical Care Clinics, Volume 35-1

Description:

This issue of Critical Care Clinics, Guest Edited by Dr.

Kenneth McCurry and Dr.

Ali Al-Khafaji, focuses on Critical Care of the Solid Organ Transplant Patient.

Dr.

McCurry’s section of the issue is devoted to Heart and Lung Transplants and includes the following topics: Long term outcomes of transplantation; Mechanical ventilation; Pulmonary hypertension therapy; Extracorporeal membrane oxygenation; Perioperative management of the lung graft following lung transplantation; Perioperative management of the heart graft following heart transplantation; Renal complications following lung and heart transplantation; and Infection and other complications following transplanation.

Dr.

Al-Khafaji’s section of the issue is devoted to Liver, Kidney, and Small Bowel Transplants and includes the following topics: The immediate postoperative period; Live donor liver transplant; Graft dysfunction and management; Extracorporeal devices; Infectious complication following solid organ transplants; and Cardiac, renal, neurological, and gastrointestinal complications.

· Section I: Heart & Lung

· Preface

· Brief Overview of Lung, Heart, and Heart-Lung Transplantation

· Key points

· Introduction

· Historical aspects of development of cardiothoracic transplantation and current trends

· Recipient selection and outcomes

· Immunosuppression

· Summary

· Bridging to Lung Transplantation

· Key points

· Introduction

· Summary/discussion

· Summary

· Perioperative Management of the Lung Graft Following Lung Transplantation

· Key points

· Introduction

· Primary graft dysfunction

· Ventilatory strategies of the transplanted lungs

· Hemodynamic management in the perioperative period

· Perioperative fluid administration and cardiac output management

· Postoperative considerations unique to patients with lung transplantation

· Perioperative considerations in patients with different underlying disease presenting for lung transplantation

· Gaps of knowledge and future directions in the perioperative care of the lung transplant patient

· Perioperative Management of the Cardiac Transplant Recipient

· Key points

· Introduction

· Hemodynamic monitoring

· Coagulopathy, bleeding, and product administration

· Vasoplegia

· Inotropic and chronotropic support

· Right ventricular failure and pulmonary hypertension

· Arrhythmia

· Ventilator support

· Renal and volume status

· Management of primary graft dysfunction

· Renal Complications Following Lung Transplantation and Heart Transplantation

· Key points

· Introduction

· Epidemiology, risk factors, and pathogenesis

· Impact of renal failure

· Diagnosis and management

· Management of chronic renal impairment

· Kidney transplantation after heart or lung transplantation

· Summary

· Infections in Heart and Lung Transplant Recipients

· Key points

· Introduction

· Epidemiology

· Risk factors

· Specific clinical syndromes

· Opportunistic infections

· Section II: Liver, Kidney, and Small Bowel

· Preface

· Perioperative Management of the Liver Transplant Recipient

· Key points

· Overview

· Process

· Candidate selection: too sick for transplant?

· Goals of care

· Postoperative management

· Hemodynamics

· Neurologic

· Respiratory

· Renal

· Gastrointestinal and nutrition

· Infection

· Hematologic considerations

· Rehabilitation

· Summary

· Critical Care Management of Living Donor Liver Transplants

· Key points

· Introduction

· The surgical procedure

· The donor

· The recipient

· Summary

· Graft Dysfunction and Management in Liver Transplantation

· Key points

· Introduction

· Vascular issues

· Primary nonfunction (and primary graft dysfunction)

· Rejection

· Post–liver transplant cholestasis

· Intrahepatic cholestasis

· Extrahepatic cholestasis

· Donor factors affecting graft function

· Extracorporeal Devices

· Key points

· Introduction

· Critical care rational for extracorporeal liver support devices

· Extracorporeal liver support systems

· Bioartificial extracorporeal liver support in acute liver failure

· Summary and challenges

· Infectious Complications Following Solid Organ Transplantation

· Key points

· Introduction

· Bloodstream infections/sepsis

· Respiratory tract infections

· Neurologic infections

· Hepatobiliary infections

· Enterocolitis

· Genitourinary infections

· Summary

· Complications of Solid Organ Transplantation: Cardiovascular, Neurologic, Renal, and Gastrointestinal

· Key points

· Background

· Cardiovascular complications

· Neurologic complications after solid organ transplantation

· Renal complications after solid organ transplantation

· Gastrointestinal complications after solid organ transplantation