Drug-Induced Liver Disease

 

Description:

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, and graduate and medical school students in these disciplines. This book supplies an in-depth discussion of drug-ind

 

 

Table of Contents:

 

PART I: MECHANISMS OF LIVER INJURY

Chapter

1. Drug-Induced Liver Disease

Chapter

2. Cytochrome P450 Activation of Toxins and Hepatoxicity

Chapter

3. Antioxidant Defense in Liver Injury: Oxidant Stress, Antioxidant Defense, and Liver Injur

Chapter

4. Hepatotxicity Due to Mitochondrial Injury

Chapter

5. Mechanisms of Cell Death and Relevance to Drug Hepatotxicity

Chapter

6. Significance of Hepatobiliary Transporters for Drug-Induced Liver Disease

Chapter

7. Immunological Mechanisms in Drug-Induced Liver Injury

Chapter

8. Mechanistic Role of Acyl Glucuronides

Chapter

9. Nonparenchymal Cells, Inflammatory Macrophages, and Hepatotxicity

Chapter

10. Role of Tissue Repair in Liver Injury

Chapter

11. Genetic Susceptibility to Drug-Induced Liver Disease

PART II: DIAGNOSIS AND MANAGEMENT

Chapter

12. Clinicapathological Patterns of Drug-Induced Liver Disease

Chapter

13. Histopathology of Drug-Induced Liver Disease

Chapter

14. Risk Factors for Drug-Induced Liver Disease

Chapter

15. Genomics, Proteomics, and Metabolomics in the Diagnosis and Mechanisms of Drug-Induced L

Chapter

16. Causality Assessment

Chapter

17. Management of the Patient with Drug-Induced Liver Disease

PART III: HEPATOTOXICITY OF SPECIFIC DRUGS

Chapter

18. Mechanisms of Acetaminophen-Induced Liver Disease

Chapter

19. Acetaminophen: Pathology and Clinical Presentation of Hepatotoxicity

Chapter

20. Mechanisms Underlying the Hepatotoxicity of Nonsteroidal Anti-inflammatory Drugs

Chapter

21. Nonsteroidal Anti-inflammatory Drugs and Leukotriene Receptor Antagonists: Pathology and

Chapter

22. Mechanism, Pathology, and Clinical Presentation of Hepatotoxicity of Anesthetic Agents

Chapter

23. Anticonvulsant Agents

Chapter

24. Hepatotoxicity of Psychotropic Drugs and Drugs of Abuse

Chapter

25. Antibacterial and Antifungal Agents

Chapter

26. Hepatotoxicity of Antituberculosis Drugs

Chapter

27. Hepatic Toxicity of Antiviral Agents

Chapter

28. Hepatotoxicity of Cardiovascular and Antidiabetic Medications

Chapter

29. Cancer Chemotherapy

Chapter

30. Hepatotoxicity of Immunomodulating Agents and the Transplant Situation

Chapter

31. Methotrexate Controversies

Chapter

32. Adverse Effects of Hormones and Hormone Antagonists on the Liver

Chapter

33. Mushroom Poisoning: A Clinical Model of Toxin-Induced Centrilobular Necrosis

Chapter

34. Hepatotoxicity of Herbal Medicines, Vitamins, and Natural Hepatotxins

Chapter

35. Occupational and Environmental Hepatotxicity

PART IV: REGULATORY PERSPECTIVES

Chapter

36. Regulatory Perspectives

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