Fertility Preservation: Principles and Practice

This new edition provides a much-needed reference book to accommodate emerging and expanding knowledge in fertility preservation, the rapidly growing field of reproductive medicine associated with advances in oncology. Written by a team of world-leading experts in the field and comprehensive in its scope, the book covers the full range of techniques and scientific concepts in detail. It opens with an introduction to fertility preservation in both cancer and non-cancer patients, followed by fertility preservation strategies in males and females, including medical/surgical procedures, ART, cryopreservation and transplantation of ovarian tissue, and in-vitro follicle culture. Concluding chapters address new technologies, as well as ethical, legal and religious issues. The book has been thoroughly updated, includes additional contributors, and now provides greater focus on practical and clinically relevant issues. Richly illustrated throughout, this is a key resource for clinicians specializing in reproductive medicine, gynecology, oncology, hematology, endocrinology and infertility.

Edited by internationally renowned specialists in gynecology, reproductive endocrinology and infertility

Covers the full range of techniques for both male and female patients, providing a comprehensive reference to established strategies and new advances in the field

Concluding chapters offer discussions of psychological, ethical, legal and reproductive issues, providing support and advice to the practicing clinician

Table of Contents

Section 1 Introduction:

1. The evolution of the assisted reproduction technologies

2. The effect of chemotherapy on the human reproductive system

3. The effect of radiotherapy on the human reproductive system

4. The need for fertility preservation in cancer patients
Section 2 Reproductive biology and cryobiology:

5. Life and death in the germ line: apoptosis and the origins of DNA damage in human spermatozooa

6. Principles of vitrification as a method of cryopreservation in reproductive biology and medicine
Section 3 Fertility preservation in cancer and non-cancer patients:

7. Fertility preservation in non-cancer patients

8. Fertility preservation in women with ovarian endometrioma: from surgery to oocyte and ovarian tissue freezing

9. Pediatric cancer therapy and fertility

10. Breast cancer therapy and fertility

11. Fertility preservation in young adults with gastrointestinal and hematological malignancies
Section 4 Fertility preservation strategies in the male:

12. Transplantation of cryopreserved spermatogonia

13. Cryopreservation and grafting of immature testicular tissue

14. Use of cryopreserved sperm and ART after chemotherapy or radiotherapy
Section 5 Fertility preservation strategies in the female: medical/surgical:

15. Use of GnRH analogs for prevention of chemotherapy-induced gonadotoxicity

16. Ovarian transposition before radiotherapy Yaron Gill and Togas Tulandi

17. Fertility-saving surgery for gynaecological cancers

18. Results of conservative management of ovarian malignant tumours
Section 6 Fertility preservation strategies in the female: ART:

19. Embryo cryopreservation as a fertility preservation strategy

20. Vitrification of human oocytes as a fertility preservation strategy

21. Autotransplantation of cryopreserved ovarian tissue: techniques and results

22. ART and oocyte donation in cancer survivors
Section 7 Ovarian cryopreservation and transplantation:

23. Ovarian cryopreservation and transplantation: overview

24. Cryopreservation of ovarian tissue by vitrification: techniques and results

25. Ovarian tissue cryopreservation

26. Risk of transplanting malignant cells in cryopreserved ovarian tissue

27. Whole ovary freezing and transplantation
Section 8 In-vitro follicle culture:

28. Molecular and cellular integrity of cultured follicles

29. In-vitro growth of human oocytes

30. Contributions of ovarian stromal cells to follicle culture

31. In-vitro maturation of germinal vesicle oocytes

32. Survival of primordial follicles: tips and tricks
Section 9 New research and technologies:

33. The artificial ovary

34. Uterus transplantation: research and clinical possibilities

35. Ovarian allotransplantation

36. Allotransplantation of human ovarian tissue

37. Predicting ovarian futures: the contribution of genetics
Section 10 Ethical, legal and religious issues:

38. Fertility preservation: ethical considerations

39. Legal issues of fertility preservation

40. Christian ethics in fertility preservation.