Hematology: Basic Principles and Practice

Description:



Extensively revised, comprehensive content from leading global contributors ensures that Hematology, 8th Edition, remains your #1 choice for expert guidance in all areas of this rapidly advancing subspecialty. This edition reflects the numerous advances that are redefining the field and dramatically influencing new approaches to diagnosis, treatment, and outcomes. Well-illustrated and clinically focused, it details the basic science and clinical practice of hematology and hematopoietic cellular therapy-covering virtually all aspects of hematology in one definitive resource.

Key Features:

• Covers all hematologic disorders, including comprehensive discussions of hematologic malignancies, individualized patient care, cell-based therapies, transplantation, transfusion medicine, hemostasis, thrombosis, and consultative hematology—in one convenient volume.
• Provides state-of-the-art guidance from global experts at the forefront of the latest research and clinical practice.
• Provides extensive updates throughout on basic science research, advances in molecular diagnostics, new drugs, immunotherapies, personalized medicine, laboratory medicine, transfusion medicine, stem cell transplantation, and clinical treatment for all hematologic malignancies and non-malignancies
• Contains new chapters on gene editing; the impact of mitochondria on hematopoiesis; myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes; immunotherapy and management of its toxicities; transfusion medicine in sickle cell disease; principles of radiation therapy; and COVID-19, including complications of vaccination and its impact on the hematologic system.
• Discusses many new advances in the field, including details and the future of gene therapy for hemophilia, gene editing for sickle cell disease and thalassemia, the evolution of cellular therapy, use of cells, transfusion medicine vs. protein therapy, gene sequencing, immunotherapy, and new targeted drugs.
• Includes more decision-making algorithms for formulating diagnoses and personalized treatment plans for those highly complex disorders that require individualized approaches.
• Addresses the effects of aging on hematopoiesis and on the manifestations of a variety of hematologic disorders.
• Discusses cardio-oncology and its impact on the treatment of patients with hematologic disorders.
• Presents relevant basic science as background for clinical application in later sections.
• An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

Table Of Contents:

PART I MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY

1. Anatomy and Physiology of the Gene

2. Epigenomics in Hematology

3. Genomic Approaches to Hematology

4. Regulation of Gene Expression in Hematology

5. Genome Editing

6. Signaling Transduction and Metabolomics

7. Protein Architecture: Relationship of Form and Function

8. Pharmacogenomics and Hematologic Diseases
PART II CELLULAR BASIS OF HEMATOLOGY

9. Hematopoietic Stem Cell Biology

10. Mitochondria and Hematopoiesis

11. Cytokines, Chemokines, Other Growth Factors, and Their Receptors

12. Role of Chemokines in Leukocyte Trafficking

13. Stem Cell Model of Hematologic Diseases

14. Hematopoietic Microenvironment

15. Cell Adhesion

16. Current Biology of Stem Cell Homing and Mobilization: Dynamic Interactions Between Hematopoietic Stem and Progenitor Cells and Their Surrounding Bone Marrow Microenvironment

17. Control of Cell Division

18. Cell Death

19. Aging and Hematopoiesis
PART III IMMUNOLOGIC BASIS OF HEMATOLOGY

20. Dendritic Cell Biology

21. Natural Killer Cell Immunity and Therapy

22. B-Cell Development

23. Complement and Immunoglobulin Biology Leading to Clinical Translation

24. T-Cell Immunity

25. Unmodified Ex Vivo Expanded T Cells

26. Treatment of Hematologic Malignancies with Genetically Modified T Cells
PART IV DISORDERS OF HEMATOPOIETIC CELL DEVELOPMENT

27. Biology of Erythropoiesis, Erythroid Differentiation, and Maturation

28. Granulocytopoiesis and Monocytopoiesis

29. Thrombocytopoiesis

30. Inherited Bone Marrow Failure Syndromes

31. Aplastic Anemia

32. Paroxysmal Nocturnal Hemoglobinuria

33. Acquired Disorders of Red Cell, White Cell, and Platelet Production
PART V RED BLOOD CELLS

34. Pathobiology of the Human Erythrocyte and Its Hemoglobins

35. Approach to Anemia in the Adult and Child

36. Iron Homeostasis and Its Disorders

37. Disorders of Iron Homeostasis: Iron Deficiency and Overload

38. Anemia of Chronic Inflammation

39. Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias

40. Megaloblastic Anemias

41. Thalassemia Syndromes

42. Pathobiology of Sickle Cell Disease

43. Clinical Aspects of Sickle Cell Disease

44. Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias

45. Red Blood Cell Enzymopathies

46. Red Blood Cell Membrane Disorders

47. Autoimmune Hemolytic Anemia

48. Extrinsic Nonimmune Hemolytic Anemias
PART VI NON-MALIGNANT LEUKOCYTES

49. Neutrophilic Leukocytosis, Neutropenia, Monocytosis, and Monocytopenia

50. Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia

51. Disorders of Phagocyte Function

52. Congenital Disorders of Lymphocyte Function

53. Pediatric and Adult Histiocytic Disorders

54. Lysosomal Storage Diseases, Focusing on Gaucher Disease: Perspectives and Principles

55. Epstein-Barr Virus and Associated Lymphoproliferative Conditions
PART VII HEMATOLOGIC MALIGNANCIES

56. Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications

57. Conventional and Molecular Cytogenomic Basis of Hematologic Malignancies

58. Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies

59. Pathobiology of Acute Myeloid Leukemia

60. Clinical Manifestations and Treatment of Acute Myeloid Leukemia

61. Myelodysplastic Syndromes

62. Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults

63. Acute Myeloid Leukemia in Children

64. Blastic Plasmacytoid Dendritic Cell Neoplasm

65. Myelodysplastic Syndromes and Myeloproliferative Neoplasms in Children

66. Pathobiology of Acute Lymphoblastic Leukemia

67. Clinical Manifestations and Treatment of Childhood Acute Lymphoblastic Leukemia

68. Acute Lymphoblastic Leukemia in Adults

69. Chronic Myeloid Leukemia

70. The Polycythemias

71. Essential Thrombocythemia

72. Primary Myelofibrosis and Chronic Neutrophilic Leukemia

73. Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes

74. Eosinophilia, Eosinophilic Neoplasms, and the Hypereosinophilic Syndromes

75. Mast Cells and Mastocytosis

76. Chronic Lymphocytic Leukemia

77. Hairy Cell Leukemia

78. The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas

79. Origin of Hodgkin Lymphoma and Therapeutic Targets

80. Hodgkin Lymphoma

81. Origin of Non-Hodgkin Lymphoma and Therapeutic Targets

82. Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma

83. Marginal Zone Lymphomas (Extranodal/MALT, Splenic, and Nodal)

84. Diffuse Large B-Cell Lymphoma of the Central Nervous System

85. High-Grade B-Cell Lymphomas

86. Mantle Cell Lymphoma

87. Virus-Associated Lymphoma

88. Malignant Lymphomas in Childhood

89. T-Cell Lymphomas

90. Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma

91. Multiple Myeloma

92. Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma

93. Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis)
PART VIII COMPREHENSIVE CARE OF PATIENTS WITH HEMATOLOGIC MALIGNANCIES

94. Key Considerations for Managing Infections in the Compromised Host

95. Principles of Radiation Therapy for Hematologic Disease

96. Grading and Toxicity Management after Immune Effector Therapy

97. Identification and Management of Checkpoint Inhibition Toxicity

98. Psychosocial Aspects of Hematologic Disorders

99. Pain Management and Antiemetic Therapy in Hematologic Disorders

100. Palliative Care

101. Therapy-related Late Effects of Hematologic Malignancies
PART IX TRANSPLANTATION AND OTHER CELL-BASED THERAPIES

102. Practical Aspects of Hematopoietic Stem Cell Harvesting and Mobilization

103. Graft Engineering and Cell Processing

104. Principles of Cell-Based Genetic Therapies

105. Indications, Outcomes, and Donor Selection for Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults

106. Unrelated Donor Hematopoietic Cell Transplantation

107. Haploidentical Hematopoietic Stem Cell Transplantation

108. Cord Blood Transplantation

109. Graft-versus-Host Disease and Graft-versus- Leukemia Responses

110. Supportive Care for the Transplant Patient
PART X TRANSFUSION MEDICINE

111. Human Blood Group Antigens and Antibodies

112. Principles of Red Blood Cell Transfusion

113. Clinical Considerations in Platelet Transfusion Therapy

114. Human Leukocyte Antigen and Human Neutrophil Antigen Systems

115. Principles of Plasma and Plasma Derivatives

116. Hemapheresis

117. Transfusion Reactions to Blood and Hematopoietic Stem Cell Therapy Products

118. Transfusion-Transmitted Diseases

119. Pediatric Transfusion Medicine

120. Transfusion and Apheresis Support for Sickle Cell Disease Patients
PART XI HEMOSTASIS AND THROMBOSIS

121. Overview of Hemostasis and Thrombosis

122. Blood Vessels

123. Megakaryocyte and Platelet Structure

124. Molecular Basis of Platelet Function

125. Molecular Basis of Blood Coagulation

126. Evaluation of the Patient with Suspected Bleeding Disorders

127. Laboratory Evaluation of Hemostatic and Thrombotic Disorders

128. Acquired Disorders of Platelet Function

129. Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura

130. Thrombocytopenia Caused by Hypersplenism, Platelet Destruction, or Surgery/Hemodilution

131. Heparin-Induced Thrombocytopenia

132. Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndromes

133. Structure, Biology, and Genetics of von Willebrand Factor

134. Hemophilia A and B

135. Rare Coagulation Factor Deficiencies

136. Transfusion Therapy for Coagulation Factor Deficiencies

137. Disseminated Intravascular Coagulation

138. Hypercoagulable States

139. Antiphospholipid Syndrome

140. Venous Thromboembolism

141. Prevention and Treatment of Venous Thromboembolism in Pregnancy

142. Atherothrombosis

143. Antithrombotic Drugs

144. Stroke

145. Acute Coronary Syndromes

146. Peripheral Artery Disease

147. Atrial Fibrillation

148. Bleeding and Clotting Disorders in Pediatrics
PART XII CONSULTATIVE HEMATOLOGY

149. Hematologic Changes in Pregnancy

150. Hematologic Manifestations of End-Organ Failure

151. Hematologic Manifestations of Solid Tumors

152. Hematologic Manifestations of HIV/AIDS

153. Hematologic Findings and Consequences of Novel Coronavirus (SARS-CoV-2) Infection

154. Hematologic Aspects of Parasitic Diseases

155. Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis

156. The Spleen and Its Disorders

157. Aging and Hematologic Disorders

158. Onco-cardiology: Focus on Cardiac Complications of Hematologic Treatments

159. Resources for the Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations

2408. e1
Chapter 159 can be found online at Elsevier eBooks for Practicing Clinicians
Index