Immune Cells, Inflammation, and Cardiovascular Diseases

Inflammation, once considered a physiological response to foreign pathogens, is now recognized as a crucial pathological player in the initiation and progression of several chronic diseases, including diabetes, obesity, cancer, Alzheimer’s disease, Parkinson’s disease, and many others. Considering that cardiovascular diseases are a leading cause of death in the United States and worldwide, the identification of critical inflammatory processes is of utmost importance to devising new immune-based therapeutics that can be added to existing regimens. This book provides detailed information on aspects of inflammation and the manner in which immune activation pathways affect the progression of cardiovascular diseases and the repair/regeneration mechanisms of underlying diseased tissues.

Key Features

• Outlines the role that inflammation plays in cardiovascular diseases
• Describes a paradox – neutralization of cytokines that contribute to cardiovascular disease does not show benefit
• Summarizes research on a variety of processes and mechanisms contributing to cardiovascular pathology
• Contributions from an international team of leading cardiologists and cardiovascular immunologists

Table of Contents:

Introduction. Shyam S. Bansal. Chapter

1. Innate Immune system in Cardiovascular　Diseases. Benjamin　J.　Kopecky　and Kory J. Lavine. Chapter

2. 　Helper T-cells　in　Cardiovascular Diseases. Vinay Kumar, Sahil Gupta, Rachel Rosenzweig, Shyam S. Bansal. Chapter

3. Glucocorticoid Signaling in Heart. Danish Sayed. Chapter

4. Transforming Growth Factor (TGF)-β/Smad□signaling in myocardial disease. Claudio　Humeres　and Nikolaos G Frangogiannis. Chapter

5. 　Fibroblast and Immune Cell crosstalk in Cardiac Repair. Stelios Psarras and Georgina　Xanthou. Chapter

6. Inflammation, Stem Cell Therapy, and Cardiac Repair. Marcus J. Wagner, Jacob T.　Menzer, and Sadia Mohsin. Chapter

7. 　Cardiovascular Complications of Immune Checkpoint Inhibitors. Sultan Tousif, Anand Prakash Singh, Prachi Umbarkar, and Hind Lal. Chapter

8. 　Neuronal Regulation of immune system in Cardiovascular Diseases. Daniela Carnevale, Giuseppe Lembo, Marialuisa Perrotta, and Lorenzo Carnevale. Chapter

9. 　Immune Responses Regulated by Exosomal Mechanisms in Cardiovascular Disease. Brooke Lee,　Ioannis　D. Kyriazis,　Ruturaj　Patil, Syed　Baseeruddin　Alvi, Amit Kumar Rai, Mahmood　Khan, and Venkata Naga Srikanth Garikipati. Chapter

10. 　Ion Channels in Immune Cells: Physiological and Pathophysiological Roles. Devasena Ponnalagu, Shridhar Sanghvi, Shyam Sunder Bansal,　and Harpreet Singh.