Mannose Binding Lectin Associated Serine Proteases

Mannose Binding Lectin Associated Serine Proteases: Structure, Function and Therapeutic Implications

provides a comprehensive and up-to-date overview of MASP-1, MASP-2, and MASP-3, highlighting their roles in immune defense, disease mechanisms, and therapeutic intervention. This authoritative reference covers the molecular structure and catalytic mechanisms of these key serine proteases, emphasizing their involvement in the lectin pathway of complement activation as well as their emerging functions in coagulation and bradykinin pathways. The book brings together the latest research on how MASPs contribute to pathogen recognition and clearance, and how their dysregulation is linked to a range of infectious, inflammatory, and thrombotic diseases. Chapters detail the biology of animal lectins and collectins, the classical and alternative complement pathways, and the specific biochemical activities of MASP-1, MASP-2, and MASP-

3. Readers will find in-depth discussions on the clinical significance of MASP gene polymorphisms and serum levels, as well as the design and therapeutic relevance of natural and synthetic MASP inhibitors. Special focus is given to the application of MASP-2 inhibitors in the management of complications such as hematopoietic stem-cell transplantation-associated thrombotic microangiopathy (HSCT-TMA). This book is an essential resource for researchers in immunology, biochemistry, and molecular medicine, as well as clinicians seeking to advance their understanding of complement biology and the therapeutic potential of targeting the lectin pathway.