Medical Microbiology

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Description: Selected for 2025 Doody’s Core Titles® with "Essential Purchase" designation in Microbiology Comprehensive, clinically oriented, and practical, Medical Microbiology, Tenth Edition, remains the go-to text for foundational coverage of key interrelated concepts in medical microbiology, immunology, and infectious diseases. Clear and engaging coverage of the microbial world and its interface with our bodies and the environment provides the foundation to understand these roles in individual and public health and disease—helping you master the essentials of microbiology to effectively prepare you for coursework, exams, and your future career.
Features:
Focuses on helping the clinician- and scientist-in-training develop a current, complete, and deeper understanding of bacteriology, immunology, virology, mycology, and parasitology, and answer the question: What information do I need to know that will help me understand how to treat an infected patient? Contains a new section of eight chapters on Infectious Diseases by Organ System for optimized clinical context. Includes clinical photographs and cases to correlate basic science with examples of clinical syndromes. Provides quick reference for efficient study with chapter summaries, key information organized in convenient tables, and review questions. Offers additional learning resources online, including over 200 self-assessment questions, microscopic images of the microbes, and more. An digital version is included with purchase. The digital allows you to access all of the text and figures, with the ability to search, customize your content, make notes and highlights, and have content read aloud Evolve Instructor site with an image and test bank is available to instructors through their Elsevier sales rep or via request at https://evolve.elsevier.com.
Table Of Contents:
Section 1. Introduction 1. Introduction to Medical Microbiology Historical Perspective Viruses Bacteria Fungi Parasites Concept of Infectious Disease Role of Diagnostic Microbiology Laboratory 2. Human Microbiome in Health and Disease Human Microbiome Project Core Microbiome Evolution of the Microbiome and Normal Flora Role of the Microbiome in Health and Disease Diagnostics and Therapeutics Perspective 3. Infection Control and Preventio Infection Prevention and Control in the Hospital Surveillance Investigating Hospital Acquired Infections Infection Prevention Program Personal Protective Equipment Antimicrobial/Diagnostic Stewardship Disinfection, Sterilization Infection Prevention and Control in the Community Emerging Infectious Diseases Personal Hygiene Vaccines Therapeutics Section 2. General Principles of Laboratory Diagnosis 4. Traditional Diagnostic Methods Microscopy Culture Identification and Antimicrobial Susceptibility Testing Serology Antibody detection Antigen detection 5. Molecular and Proteomic Method Microbial Detection Microbial Identification Epidemiologic Typing Section 3. Basic Concepts in the Immune Response 6. Elements of Host Protective Responses Overview of the immune system as a system Soluble Activators and Stimulators of Innate and Immune Functions Cells of the Immune Response 8. Innate Host Responses Barriers to Infection Soluble Components of Innate Responses Cellular Components of Innate Responses Activation of Innate Cellular Responses Normal Flora–Associated Responses Inflammation Bridge to Antigen-Specific Immune Responses 9. Antigen-Specific Immune Responses Immunogens, Antigens, and Epitopes T Cells Cell-Surface Receptors of T Cells Development of T Cells Initiation of T-Cell Responses Activation of CD4 T Cells and Their Response to Antigen CD8 T Cells INNATE T Cells B Cells and Humoral Immunity B cells Immunoglobulin Types and Structures Immunogenetics Antibody Response 10. Immune Responses to Infectious Agents Antibacterial Responses Antiviral Responses Specific Immune Responses to Fungi Specific Immune Responses to Parasites Other Immune Responses Immunopathogenesis Autoimmune Responses Immunodeficiency11. Antimicrobial Vaccines Types of Immunizations Immunization Programs Section 4. Bacteriology 12. Bacterial Classification, Structure, and Replication Differences between Eukaryotes and Prokaryotes Bacterial Classification Bacterial Structure Bacterial metabolism Bacterial Genetics 13. Bacterial Metabolism and Genetics Bacterial Metabolism Human Bacterial Metabolism Bacterial Genes and Expression Bacterial Genetics 14. Pathogenesis of Bacterial Diseases Entry into the Human Body Colonization, Adhesion, and Invasion Pathogenic Actions of Bacteria Immunopathogenesis Mechanisms for Escaping Host Defenses Summary 15. Role of Bacteria in Disease 16. Laboratory Diagnosis of Bacterial Diseases 17. Antibacterial Agents Inhibition of Cell Wall Synthesis Inhibition of Protein Synthesis Inhibition of Nucleic Acid Synthesis Other Antibiotics 18. Staphylococcus and Related Gram-Positive Cocci Physiology and Structure Pathogenesis and Immunity Epidemiology Clinical Diseases Staphylococcus aureus Staphylococcus, other species Laboratory Diagnosis Treatment, Prevention, and Control 19. Streptococcus and Enterococcus General Properties Streptococcus pyogenes Streptococcus agalactiae Other ß-Hemolytic Streptococci Viridans Streptococci Streptococcus pneumoniae Enterococcus 20. Bacillus Bacillus anthracis Bacillus cereus 21. Listeria and Related Gram-Positive Bacteria Listeria monocytogenes Erysipelothrix rhusiopathiae Corynebacterium diphtheriae 22. Mycobacterium and Related Acid-Fast Bacteria Physiology and Structure of Mycobacteria Mycobacterium Tuberculosis Other Slow-Growing Mycobacteria Rapidly Growing Mycobacteria Nocardia Other Weakly Acid-Fast Bacteria 23. Neisseria and Related Genera Neisseria gonorrhoeae and Neisseria meningitidis Other Neisseria Species 24. Haemophilus and Related Bacteria Haemophilus 25. Enterobacteriales General Properties Escherichia coli Salmonella Shigella Yersinia Other Enterobacteriales Other General Properties 26. Vibrio and Related Bacteria Vibrio Aeromonas 27. Pseudomonas and Related Bacteria Pseudomonas Burkholderia Stenotrophomonas maltophilia Acinetobacter Moraxella 28. Campylobacter and Helicobacter Campylobacter Helicobacter 29. Miscellaneous Gram-Negative Rods Bartonella Bordetella Other Bordetella Species Brucella Cardiobacterium Francisella Legionella Streptobacillus 30. Clostridium Clostridium difficile Clostridium perfringens Clostridium tetani Clostridium botulinum Other Clostridial Species 31. Non–Spore-Forming Anaerobic Bacteria Anaerobic Gram-Positive Cocci Anaerobic Gram-Positive Rods Anaerobic Gram-Negative Cocci Anaerobic Gram-Negative Rods 32. Treponema, Borrelia, and Leptospira Treponema Borrelia Leptospira 33. Mycoplasma Physiology and Structure Pathogenesis and Immunity Epidemiology Clinical Diseases Laboratory Diagnosis Treatment, Prevention, and Control 34. Rickettsia, Ehrlichia, and Related Bacteria Rickettsiaceae Anaplasmataceae Coxiellaceae 35. Chlamydia Physiology and Structure Chlamydia trachomatis Chlamydia pneumoniae Chlamydia psittaci Section 5. Virology 36. Viral Classification, Structure, and Replication Classification Virion Structure Viral Replication Viral Genetics Viral Vectors for Therapy 37. Pathogenesis of Viral Diseases Basic Steps in Viral Disease Infection of the Target Tissue Viral Pathogenesis Viral Disease Epidemiology Control of Viral Spread38. Role of Viruses in Disease Viral Diseases Chronic and Potentially Oncogenic Infections Infections in Immunocompromised Patients Congenital, Neonatal, and Perinatal Infections 39. Laboratory Diagnosis of Viral Diseases Specimen Collection Cytology Electron Microscopy Viral Isolation and Growth Detection of Viral Genetic Material Detection of Viral Proteins Viral Serology 40. Antiviral Agents and Infection Control Targets for Antiviral Drugs Nucleoside Analogs Nonnucleoside Polymerase Inhibitors Protease Inhibitors Antiinfluenza Drugs Immunomodulators Infection Control 41. Papillomaviruses and Polyomaviruses Human Papillomaviruses Polyomaviridae 42. Adenoviruses Structure and Replication Pathogenesis and Immunity Epidemiology Clinical Syndromes Laboratory Diagnosis Treatment, Prevention, and Control Therapeutic Adenoviruses 43. Human Herpesviruses Structure of Herpesviruses Herpesvirus Replication Herpes Simplex Virus Varicella-Zoster Virus Epstein-Barr Virus Cytomegalovirus Human Herpesviruses 6 and 7 Other Human Herpesviruses 44. Poxviruses Structure and Replication Pathogenesis and Immunity Epidemiology Clinical Syndromes 45. Parvoviruses Structure and Replication Pathogenesis and Immunity Epidemiology Clinical Syndromes Laboratory Diagnosis Treatment, Prevention, and Control 46. Picornaviruses Structure Replication Enteroviruses Rhinoviruses 47. Coronaviruses and Noroviruses Coronaviruses Noroviruses 48. Paramyxoviruses Structure and Replication Measles Virus Parainfluenza Viruses Mumps Virus Respiratory Syncytial Virus Human Metapneumovirus Nipah and Hendra Viruses 49. Orthomyxoviruses Structure and Replication Pathogenesis and Immunity Epidemiology Clinical Syndromes Laboratory Diagnosis Treatment, Prevention, and Control 50. Rhabdoviruses, Filoviruses, and Bornaviruses Rhabdoviruses Filoviruses Borna Disease Virus 51. Reoviruses Structure Replication Rotaviruses Orthoreoviruses (Mammalian Reoviruses) Coltiviruses and Orbiviruses 52. Togaviruses and Flaviviruses Alphaviruses and Flaviviruses Rubella Virus 53. Bunyaviridae and Arenaviridae Bunyaviridae Arenaviruses 54. Retroviruses Classification Structure Replication Human Immunodeficiency Virus Human T-Cell Lymphotropic Virus and Other Oncogenic Retroviruses Endogenous Retroviruses 55. Hepatitis Viruses Hepatitis A Virus Hepatitis B Virus Hepatitis C and G Viruses Hepatitis G Virus Hepatitis D Virus Hepatitis E Virus 56. Prion Diseases Structure and Physiology Pathogenesis Epidemiology Clinical Syndromes Laboratory Diagnosis Treatment, Prevention, and Control Section 6. Mycology 57. Fungal Classification, Structure, and Replication The Importance of Fungi Fungal Taxonomy, Structure, and Replication Ascomycota (Ascomycetes) Basidiomycota (Basidiomycetes) Glomerulomycota (Mucormycetes, formerly Zygomycetes) Microspora (Microsporidia) Classification of Human Mycoses Summary 58. Pathogenesis of Fungal Disease Primary Fungal Pathogens Opportunistic Pathogens 59. Role of Fungi in Disease 60. Laboratory Diagnosis of Fungal Disease Clinical Recognition of Fungal Infections Conventional Laboratory Diagnosis Immunologic, Molecular, and Biochemical Markers for Direct Detection of Invasive Fungal Infections 61. Antifungal Agents Systemically Active Antifungal Agents Topical Antifungal Agents Investigational Antifungal Agents Combinations of Antifungal Agents in the Treatment of Mycoses Mechanisms of Resistance to Antifungal Agents 62. Superficial and Cutaneous Mycoses Superficial Mycoses Cutaneous Mycoses 63. Subcutaneous Mycoses Lymphocutaneous Sporotrichosis Chromoblastomycosis Eumycotic Mycetoma Subcutaneous Entomophthoromycosis Subcutaneous Phaeohyphomycosis 64. Systemic Mycoses Caused by Dimorphic Fungi Blastomycosis Coccidioidomycosis Emergomycosis and Adiaspiromycosis Histoplasmosis Paracoccidioidomycosis Talaromycosis (Penicilliosis) marneffei 65. Opportunistic Mycoses Candidiasis Opportunistic Mycoses Caused by Cryptococcus Neoformans and Other Noncandidal Yeastlike Fungi Microsporidia Aspergillosis Mucormycosis Mycoses Caused by Other Hyaline Molds Phaeohyphomycosis Pneumocystosis 66. Fungal and Fungal-Like Infections of Unusual or Uncertain Etiology Adiaspiromycosis Chlorellosis Lacaziosis (Lobomycosis) Protothecosis Pythiosis Insidiosi Lagenidiosis Rhinosporidiosis Section 7. Parasitology 67. Parasitic Classification, Structure, and Replication Importance of Parasites Classification and Structure Physiology and Replication Summary 68. Pathogenesis of Parasitic Diseases Exposure and Entry Adherence and Replication Cell and Tissue Damage Disruption, Evasion, and Inactivation of Host Defenses 69. Role of Parasites in Disease 70. Laboratory Diagnosis of Parasitic Disease Parasite Life Cycle as an Aid in Diagnosis General Diagnostic Considerations Parasitic Infections of the Intestinal and Urogenital Tracts Parasitic Infections of Blood and Tissue Alternatives to Microscopy 71. Antiparasitic Agents Targets for Antiparasite Drug Action Drug Resistance Antiparasitic Agents 72. Intestinal and Urogenital Protozoa Amebae (Amoebozoa) Ciliates (Metamonada [Formerly Flagellates] and Ciliophora) Sporozoa (Apicomplexa) 73. Blood and Tissue Protozoa Plasmodium Species Babesia Species Toxoplasma gondii Sarcocystis lindemanni Free-Living Amebae Leishmania Trypanosomes 74. Nematodes Enterobius vermicularis Ascaris lumbricoides Toxocara and Baylisascaris Trichuris trichiura Hookworms Strongyloides stercoralis Trichinella spiralis Wuchereria bancrofti and Brugia malayi Loa loa Mansonella Species Onchocerca volvulus Dirofilaria immitis Dracunculus medinensis 75. Trematodes Fasciolopsis buski Fasciola hepatica Clonorchis sinensis Paragonimus westermani Schistosomes 76. Cestodes Taenia solium Cysticercosis Taenia saginata Diphyllobothrium latum Sparganosis Echinococcus granulosus Echinococcus multilocularis Hymenolepis nana Hymenolepis diminuta Dipylidium caninum 77. Arthropods Myriapoda Crustacea Pentastomida Chelicerata (Arachnida) Hexapoda (Insecta) Section 8. Infectious Diseases by Organ System 78. Sepsis and Cardiovascular Infections Vignette Specific specimen sites and the collection/transport of the specimens summary table most likely pathogens summary table 79. Ear, Nose, and Throat Infections Vignette Specific specimen sites and the collection/transport of the specimens summary table most likely pathogens summary table 80. Lower Respiratory Tract Infections Vignette Specific specimen sites and the collection/transport of the specimens summary table most likely pathogens summary table 81. Ocular and Central Nervous System Infections Vignette Specific specimen sites and the collection/transport of the specimens summary table most likely pathogens summary table 82. Genitourinary Tract Infections Urinary tract infections Vignette Specific specimen sites and the collection/transport of the specimens summary table most likely pathogens summary table Sexually transmitted genital infections Vignette Specific specimen sites and the collection/transport of the specimens summary table most likely pathogens summary table 83. Gastrointestinal Tract Infections Vignette Specific specimen sites and the collection/transport of the specimens summary table most likely pathogens summary table 84. Intraabdominal Infections Vignette Specific specimen sites and the collection/transport of the specimens summary table most likely pathogens summary table 85. Musculoskeletal, Skin, and Soft Tissue Infections Vignette Specific specimen sites and the collection/transport of the specimens summary table most likely pathogens summary table APPENDIX Classic References to Know (ASM manual, CDC, Trop Dis, etc)