Osteoporosis, 4th Edition

Features:

• Summarizes the latest research in bone biology and translational applications in a range of new therapeutic agents, including essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, parathyroid hormone, and new therapeutic agents
• Recognizes the critical importance of new signaling pathways for bone health, including Wnt, OPG and RANK, of interest to both researchers who study bone biology and clinicians who treat osteoporosis
• Offers new insights into osteoporosis associated with menopause, pre-menopause, chronic kidney disease, diabetes, HIV and other immune disorders

Table Of Contents:

Volume

1.
Part I. Introduction

1. The Nature of Osteoporosis

2. The Bone Organ System: Form and Function
Part II. Developmental, Cellular and Molecular Biology of Bone

3. Development of the Skeleton

4. The Skeletal Stem Cell

5. Osteoclast Biology

6. Osteoblast Biology: Developmental Origin and Interactive Nature of Osteoblasts

7. Osteocytes

8. The Regulatory Role of Matrix Proteins in Mineralization of Bone
Part III. Skeletal Hormones and Regulatory Factors

9. Parathyroid Hormone and Parathyroid Hormone-Related Protein

10. Phosphatonins

11. Skeletal Growth Factors

12. WNT Signaling in Skeletal Homeostasis and Diseases
Part IV. Biomechanics and Mechanobiology

13. The Mechanical Behavior of Bone

14. Cellular and Molecular Mechanotransduction in Bone

15. Adaptation of Skeletal Structure to Mechanical Loading

16. Biomechanics of Hip and Vertebral Fractures
Part V. Epidemiology of Osteoporosis

17. Epidemiologic Methods in Studies of Osteoporosis

18. Genetics of Osteoporosis

19. Race, Ethnicity, and Osteoporosis

20. Geographic Variability in the Incidence of Hip and Vertebral Fractures

21. Nutrition and Osteoporosis

22. Physical Activity, Exercise and Skeletal Health

23. Reproductive and Hormonal Factors and the Risk for Osteoporosis

24. Clinical and Epidemiological Studies: Skeletal Changes across Menopause

25. Osteoporosis in Men: What is Similar and What is Different?

26. Falls as Risk Factors for Fracture

27. Impact of Physical Characteristics and Lifestyle Factors on Bone Density and Fractures

28. Imminent Fracture Risk and Disability Post Fracture

29. Economics of Osteopososis
Part VI. General Pathophysiology of Osteoporosis

30. Skeletal Heterogeneity and the Purposes of Bone Remodeling

31. On the Evolution and Contemporary Roles of Bone Remodeling

32. Estrogen Deficiency and the Pathogenesis of Osteoporosis

33. Cytokines and the Pathogenesis of Osteoporosis

34. Bone and Fat

35. Bone, Muscle, and Sarcopenia

36. Bone Mineral Acquisition in Utero and During Infancy and Childhood

37. Osteoporosis in Childhood and Adolescence

38. Osteoporosis in Premenopausal Women, Pregnancy, and Lactation

39. Bone and the Microbiome

Volume

2.
Part VII. Impact of Comorbidity and Medications on Skeletal Health

40. Immobilization Osteoporosis

41. Osteoporosis in Neurological Disorders: Parkinson’s Disease, Stroke, and Multiple Sclerosis--July 28, 2019

42. Effects on the Skeleton from Medications Used to Treat Non-skeletal Disorders

43. Osteoporosis associated with gastrointestinal disorders; celiac and inflammatory bowel diseases

44. Osteoporosis Associated with Eating Disorders

45. Glucocorticoid-Induced Osteoporosis and Cushing's Syndrome

46. Thyroid Hormone, Thyroid Medication, and the Skeleton

47. The Skeletal Actions of Parathyroid Hormone in Primary Hyperparathyroidism

48. Osteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult Osteoporosis

49. Human Immunodeficiency Virus and Osteoporosis

50. Diabetes, Diabetic Medications, and Risk of Fracture

51. Skeletal Health after Bariatric Surgery

52. Osteoporosis in Organ Transplant Patients

53. Osteoporosis Associated with Rheumatologic Disorders

54. Osteoporosis Associated with Chronic Kidney Disease

55. Relationship Between Periodontal Disease, Tooth Loss and Osteoporosis

56. Impact of Breast Cancer and its treatment on Bone Loss and Fracture Risk – Pathophysiology and Management

57. Management of Bone Health in Men with Prostate Cancer

58. Impact of MGUS and Myeloma on Skeletal Health

59. Renal Stone Disease, Hypercalciuria and Osteoporosis: Use of Thiazides and Alkali for Osteoporosis

60. Sleep Disorders and Osteoporosis
Part VIII. Diagnosis and Evaluation

61. Evaluation of the Osteoporosis Patient

62. Who Should be Screened for Osteoporosis?

63. Vertebral Fracture Identification

64. Noninvasive Imaging Techniques and Fracture Risk Assessment

65. Biochemical Markers of Bone Turnover in Osteoporosis

66. A Comparison of Fracture Risk Assessment Tools
Part IX. Patient Management

67. Orthopedic Aspects of Osteoporosis

68. Fall Prevention Interventions

69. Exercise and Other Physical Therapy Interventions in the Management of Osteoporosis

70. Calcium and Vitamin D in the Management of Osteoporosis

71. Nutrients Beyond Calcium and Vitamin D to Treat Osteoporosis

72. Condition Still Critical: Compliance and Persistence with Osteoporosis Medications
Part X. Pharmacotherapeutics

73. Estrogen and Estrogen Analogs for Prevention and Treatment of Osteoporosis

74. Bisphosphonates Pharmacology and Use in the Treatment of Osteoporosis

75. Denosumab for the Treatment of Osteoporosis

76. Teriparatide and Abaloparatide Treatment for Osteoporosis

77. Calcitonin in Osteoporosis

78. Androgens

79. Long-term Bisphosphonate Treatment: Continuation and Interruption

80. Romosozumab in the Treatment of Postmenopausal Osteoporosis

81. Lessons from Bone Histomorphometry on the Mechanisms of Action of Osteoporosis Drugs
Part XI. New Directions

82. Longterm Treatment Strategies and Goal Directed Therapy