Parkinson Disease,An Issue of Clinics in Geriatric Medicine (Volume 36-1)

This issue of Clinics in Geriatric Medicine, guest edited by Drs.

Carlos Singer and Stephen G.

Reich, is devoted to Parkinson Disease.

Articles in this issue include: Parkinson Disease: An overview of epidemiology, pathology, genetics and pathophysiology; Diagnosis and Differential Diagnosis of Parkinson Disease; Tremor in the Elderly: Is it Parkinson Disease?

; Management of Early Parkinson Disease; Management of Advanced Parkinson Disease; Orthostatic Hypotension in Parkinson Disease; Management of Urological and Sexual Dysfunction in Parkinson Disease; Gastrointestinal Care of the Parkinson Patient; Cognitive Impairment and Dementia in Parkinson Disease; Depression and Anxiety in Parkinson Disease; Hallucinations, Delusions, and Impulse Control Disorders in Parkinson Disease; Sleep Disorders in Parkinson Disease; Orthopedic Care of the Parkinson Patient; Driving in Parkinson Disease; Palliative Care in Parkinson Disease; Multidisciplinary Care of Parkinson Disease: Fall prevention, fatigue, exercise, rehabilitative therapies, caregiver strain; and Hospitalization of the Patient with Parkinson Disease.

· Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology

· Key points

· Introduction

· Neuropathology

· Epidemiology

· Genetics and pathophysiology

· Alpha-synuclein aggregation and spread of pathology

· Summary

· Diagnosis and Differential Diagnosis of Parkinson Disease

· Key points

· Introduction

· Parkinson disease

· Multiple system atrophy

· Progressive supranuclear palsy

· Corticobasal degeneration

· Dementia with Lewy bodies

· Vascular parkinsonism

· Summary

· Disclosure

· Does This Patient Have Parkinson Disease or Essential Tremor?

· Key points

· Just when you thought you could distinguish Parkinson disease from essential tremor

· Some other types of tremor in the elderly

· Management of Early Parkinson Disease

· Key points

· Introduction

· Early Parkinson disease

· Pharmacologic agents for early Parkinson disease

· Treatment strategies in early Parkinson disease

· Levodopa: early versus delayed use

· Nonmotor symptoms

· Surgical treatment of Parkinson disease

· Exercise in Parkinson disease

· Summary

· Management of Motor Features in Advanced Parkinson Disease

· Key points

· Introduction

· Defining fluctuations and dyskinesias

· Treatment of motor fluctuations associated with levodopa treatment

· Treatment of dyskinesias associated with levodopa treatment

· Advanced treatments of Parkinson disease

· Management of motor symptoms refractory to dopaminergic therapy

· Summary

· Orthostatic Hypotension in Parkinson Disease

· Key points

· Introduction

· Epidemiology

· Pathophysiology

· Approach to the patient with orthostatic hypotension

· Diagnosis of neurogenic orthostatic hypotension

· Management of neurogenic orthostatic hypotension

· Neurogenic supine hypertension

· Summary

· Management of Urologic and Sexual Dysfunction in Parkinson Disease

· Key points

· Introduction

· Anatomy/pathophysiology

· Management of urinary symptoms

· Management of disorders of sexual performance

· Management of disorders of sexual desire (libido)

· Summary

· Gastrointestinal Care of the Parkinson Patient

· Key points

· Introduction

· Weight loss

· Drooling

· Dysphagia

· Gastroparesis

· Defecatory dysfunction

· Constipation

· Effects of Parkinson disease therapies on gastrointestinal symptoms

· Summary

· Depression and Anxiety in Parkinson Disease

· Key points

· Introduction

· Epidemiology

· Classification

· Risk factors for depression and anxiety

· Scales

· Pharmacologic intervention

· Optimizing dopaminergic treatment

· Nonpharmacologic therapy

· Management of anxiety

· Summary

· Hallucinations, Delusions and Impulse Control Disorders in Parkinson Disease

· Key points

· Introduction

· Approach to compulsive and psychotic symptoms in Parkinson disease

· Delirium in Parkinson disease

· Chronic psychosis in Parkinson disease

· Impulse control disorders in Parkinson disease

· Summary

· Overview of Sleep and Circadian Rhythm Disorders in Parkinson Disease

· Key points

· Introduction

· Most common sleep disorders associated with Parkinson disease

· Summary

· Orthopedic Care of Patients with Parkinson Disease

· Key points

· Introduction

· Causes of fall-related fractures in Parkinson disease

· Orthopedic interventions for shoulder problems in Parkinson disease

· Spine surgery in Parkinson disease

· Knee and hip surgery in Parkinson disease

· Cognitive decline and orthopedic surgeries in patients with Parkinson

· Summary

· Driving in Parkinson Disease

· Key points

· Epidemiology of driving issues in Parkinson disease

· Neurological substrates of driving issues

· Naturalistic studies

· Simulator studies

· Road studies

· Driving rehabilitation

· Policy issues

· Future of driving in Parkinson disease

· Summary

· Palliative Care for Parkinson Disease

· Key points

· Relevance of palliative care to Parkinson disease

· Summary

· Multidisciplinary Care to Optimize Functional Mobility in Parkinson Disease

· Key points

· Introduction

· Assessment of functional mobility

· Multidisciplinary management to improve functional mobility

· Organization of multidisciplinary care

· Summary

· Hospital Management of Parkinson Disease Patients

· Key points

· Introduction

· Causes of urgent and elective hospitalization in patients with Parkinson disease

· Care of patients with Parkinson disease in the hospital setting

· Perioperative care

· Strategies to minimize hospitalization in Parkinson disease

· Palliative care