Pubertal Suppression in Transgender Youth, 1e

Description:

Offering current guidelines on the relatively new practice of puberty suppression for gender-dysphoric adolescents, Pubertal Suppression in Transgender Youth provides a succinct, easy-to-digest overview of this timely topic. This concise, clinically-focused resource by Dr. Courtney Finlayson covers all relevant topics, from a brief history of medical care of transgender youth to emerging developments in the field.

Table of Contents

· Copyright

· List of Contributors

· Chapter

1. History of Care of Transgender Youth

· Dedication

· Chapter

2. Models of Care and Current Guidelines for Care of Transgender Individuals

· Gender-Affirming Care

· Multidisciplinary Care

· Practice Guidelines

· Mental Healthcare

· Medical Care

· Adjunctive Services

· Barriers to Care

· Summary

· Chapter

3. Puberty

· Physical Changes Associated With Puberty

· Physiology of Puberty

· Delayed Puberty or Absent Puberty (Sexual Infantilism)

· Precocious Puberty (Sexual Precocity)

· Chapter

4. GnRH Analogs (Mechanism, Past Studies, Drug Options, Use in Precocious Puberty, Use in Gender-Nonconforming Youth)

· Historical Perspective

· Physiology and Mechanism of Action

· Use in Central Precocious Puberty

· Outcomes in Central Precocious Puberty

· Use in Gender-Nonconforming Youth

· Options for Treatment

· Outcomes in Gender-Nonconforming Youth

· Challenges in Care

· Conclusion

· Chapter

5. Rationale for the Initiation, Use, and Monitoring of GnRHa in Gender Non-conforming Youth

· Introduction

· Rationale

· Initiation

· Monitoring

· Conclusion

· Chapter

6. Psychosocial Considerations in Pubertal Suppression Treatment

· Introduction

· Possible Effects of Gonadotropin-Releasing Hormone Analogues on Gender Identity and/or Sexuality Development

· Unknown Neurocognitive Sequelae of Pubertal Suppression Treatment

· Psychosocial Implications of Known Medical Side Effects of Gonadotropin-Releasing Hormone Analogue Treatment

· Family Factors

· Conclusion

· Chapter

7. Medical Side Effects of GnRH Agonists

· Bone Health

· Brain

· Fertility

· Body Mass Index and Body Composition

· Summary

· Chapter

8. Surgical Side Effects of GnRHa

· Introduction

· Goals of Surgery

· Timing of Surgery

· Surgical Considerations for Individuals on GnRHa

· Areas of Uncertainty

· Conclusion

· Chapter

9. Fertility Preservation: Considerations for Gender-Diverse Youth

· Risk of Infertility due to Hormonal Therapies

· Fertility Preservation Options in Birth-Assigned Males

· Fertility Preservation Options in Birth-Assigned Females

· Attitudes Toward FP and Other Psychological Considerations

· Ethical Considerations

· Financial Considerations

· Future Directions

· Conclusions

· Chapter

10. Duration of Pubertal Suppression and Initiation of Gender-Affirming Hormone Treatment in Youth

· Pubertal Suppression and Gender-Affirming Hormone Therapies

· Relevant Time Points in Clinical Guidelines and Protocols

· Unresolved Questions

· Case Examples

· Initiation of Gender-Affirming Hormones

· Testosterone

· Estrogen

· Conclusions

· Chapter

11. Ethical Considerations of GnRHa Treatment and Consent Process

· Introduction

· Pubertal Suppression

· Benefits of Pubertal Suppression

· Ethical Issues

· Conclusion

· Chapter

12. Emerging Developments in Pubertal Suppression for Gender Incongruent/Gender Dysphoric Youth

· Triptorelin, a New Gonadotropin-Releasing Hormone Agonist

· Prolonged Use of Histrelin acetate implant in Transgender Youth

· Gonadotropin-Releasing Hormone Agonist Use in Nonbinary Youth

· Gonadotropin-Releasing Hormone and Gonadotropin Antagonists

· Kisspeptin and Neurokinin B Antagonists

· Oxandrolone as an Alternative Gender-Affirming Masculinizing Hormone

· Low-Dose Estrogen and Testosterone

· Antiandrogens and Androgen Receptor Inhibitors

· Antiandrogens

· Conclusion