Rang & Dale’s Pharmacology

Description:

Rang and Dale’s Pharmacology is internationally acknowledged as the core textbook for students of pharmacology, and has provided accessible, up-to-date information on drugs and their mechanism of action for more than 30 years.

Now in its tenth edition, it has been updated to include important new drugs such as gene therapies, personalised medicines and the new wave of RNA drugs. However it has not lost any of the elements that have contributed to its popularity, such as color coding and illustrations, making it reader-friendly while comprehensively covering the depth of detail required.

This essential book is recommended as the first-choice undergraduate text for science and medical students and junior doctors and will also be useful for students in other professional disciplines such as pharmacy, veterinary medicine and nursing.

New To This Edition:

• New chapters on drugs and the eye and the pharmacological management of headache
• Revised information on biopharmaceuticals (including RNA drugs), antivirals (including Covid-19 therapies) as well as general principles of antimicrobial therapy.
• A completely revised and updated chapter on lifestyle drugs
• Recent advances in oxygen sensing and response to reduced oxygen tension
• Expanded chapters on dementia and analgesic drugs

Table Of Contents:

Section 1 GENERAL PRINCIPLES

1. What is pharmacology?

2. How drugs act: general principles

3. How drugs act: molecular aspects

4. How drugs act: cellular aspects - excitation, contraction and secretion

5. How drugs act: Biopharmaceuticals and gene therapy

6. Cell proliferation, apoptosis, repair and regeneration

7. Cellular mechanisms: host defence

8. Method and measurement in pharmacology

9. Absorption and distribution of drugs

10. Drug metabolism and elimination

11. Pharmacokinetics

12. Individual variation, pharmacogenomics and personalised medicine
Section 2 CHEMICAL MEDIATORS

13. Chemical mediators and the autonomic nervous system

14. Cholinergic transmission

15. Noradrenergic transmission

16. 5-Hydroxytryptamine and purines

17. Histamine and the biologically active lipids

18. Cannabinoids

19. Nitric oxide and related mediators
Section 3 DRUGS AFFECTING MAJOR ORGAN SYSTEMS

20. The heart

21. The vascular system

22. Atherosclerosis and lipoprotein metabolism

23. Haemostasis and thrombosis

24. Haemopoietic system and treatment of anaemia

25. Anti-inflammatory and immunosuppressant drugs

26. Skin

27. Eye

28. Respiratory system

29. The kidney and urinary system

30. The gastrointestinal tract

31. The control of blood glucose and drug treatment of diabetes mellitus

32. Obesity

33. The pituitary and the adrenal cortex

34. Thyroid

35. The reproductive system

36. Bone metabolism
Section 4 NERVOUS SYSTEM

37. Chemical transmission and drug action in the central nervous system

38. Amino acid transmitters

39. Other transmitters and modulators

40. Neurodegenerative diseases

41. General anaesthetic agents

42. Headache

43. Analgesic drugs

44. Local anaesthetics and other drugs affecting sodium channels

45. Anxiolytic and hypnotic drugs

46. Antiepileptic drugs

47. Antipsychotic drugs

48. Antidepressant drugs

49. Psychoactive drugs

50. Drug abuse and dependence
Section 5 DRUGS USED FOR THE TREATMENT OF INFECTIONS AND CANCER

51. Basic principles of antimicrobial chemotherapy

52. Antibacterial drugs

53. Antiviral drugs

54. Antifungal drugs

55. Antiprotozoal drugs

56. Antihelminthic drugs

57. Anticancer drugs
Section 6 SPECIAL TOPICS

58. Harmful effects of drugs

59. Lifestyle drugs and drugs in sport

60. Drug discovery and development