Williams Hematology: The Red Cell and Its Diseases

Everything you need to know about red cell disorders, from basic science to clinical application.

When red blood cells do not have enough hemoglobin, oxygen cannot reach all parts of the body—as a result, organs start to malfunction and may lead to a host of issues including deformities, enlarged spleen, heart problems and other diseases. There are myriad red cell disorders, such as iron deficiency anemia, pernicious anemia, aplastic anemia, autoimmune hemolytic anemia, sickle cell, thalassemia and other hemoglobinopathies.

The Red Cells and its Diseases provides clinicians with a practical diagnostic and treatment framework for identifying and successfully managing acute, congenital, and chronic red blood cell disorders. Presented in an accessible template format, the book includes classifications, etiology and pathogenesis, clinical and laboratory features, differential diagnosis, treatment, management, and supportive care.

This comprehensive, yet concise resource covers:

Structure and physiology of the red cell

Classification of red cell diseases

Diseases of red cell production

Anemias resulting principally from inherited disorders

Anemia as a result of exogenous factors

Polyclonal erythrocytosis

Red cell transfusion

Table of Contents:

Part

1. Structure and Physiology of the Red Cell

Chap. 1 Structure of the Red Cell

Chap

2. Erythropoiesis and Red Cell turnover

Part

2. Classification of Red cell Diseases

Chap.

3. Clinical Manifestations and Classification of Red

Cell Disorders

Part

3. Diseases of Red Cell Production

Chap

4. Aplastic Anemia

Chap

5. Erythroid Aplasia

Chap

6. Anemia of Chronic Inflammation

Chap

7. Erythropoietic effects of endocrine disorders

Chap

8. Paroxysmal nocturnal hemoglobinuria

Chap

9. Folate, Cobalamin and the megaloblastic anemia

Chap

10. Iron Metabolism

Chap.

11. Iron deficiency anemia

Chap

12. Anemia resulting from other nutritional

deficiencies

Chap

13. Anemia associated with marrow infiltration

Part

4. Anemias as a result principally of inherited

disorders

Chap

14. Congenital (inherited) dyserythropoietic anemias

Chap

15. Erythrocyte membrane disorders

Chap

16. Erythrocyte Enzyme disorders

Chap

17. The thalassemias

Chap

18. Disorders of hemoglobin structure: Sickle cell

anemia and related abnormalities

Chap

19. Methemoglobinemia and other

dyhemoglobinemias

Chap

20. Polyclonal hereditary and acquired sideroblastic

anemia

Chap

21. The porphyrias

Part

5. Anemia as a result of exogenous factors

Chap

22. Fragmentation hemolytic anemia

Chap

23. Erythrocyte disorders as a result of chemicals,

metals, and other toxic agents

Chap

24. Hemolytic anemia as a result of infections with

microorganisms

Chap

25. Hypersplenism and hyposplenism

Chap

26. Immune hemolytic anemia

Chap

27. Alloimmune hemolytic disease of the fetus and

newborn

Part

6. Erythrocytosis

Chap

27. Primary and secondary erythrocytosis

Part

7. Red Cell Transfusion

Chap

28. Erythrocyte antigens and antibodies

Chap

29. Blood procurement and red cell transfusion