Fetal and Neonatal Physiology, 2-Volume Set

Description:


Offering the comprehensive, authoritative information needed for effective diagnosis, treatment, and management of sick and premature infants, Fetal and Neonatal Physiology, 6th Edition, is an invaluable resource for board review, clinical rounds, scientific research, and day-to-day practice.

This trusted two-volume text synthesizes recent advances in the field into definitive guidance for today’s busy practitioner, focusing on the basic science needed for exam preparation and key information required for full-time practice.

It stands alone as the most complete text available in this complex and fast-changing field, yet is easy to use for everyday application.

 

 

Key Features:

 

• Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants.

   

• Contains new chapters on Pathophysiology of Genetic Neonatal Disease, Genetic Variants and Neonatal Disease, and Developmental Biology of Lung Stem Cells,  as well as significantly revised chapters on Cellular Mechanisms of Neonatal Brain Injury, Neuroprotective Therapeutic Hypothermia, Enteric Nervous System Development and Gastrointestinal Motility, and Physiology of Twin-Twin Transfusion.

   

• Features 1,000 full-color diagrams, graphs and anatomic illustrations, 170+ chapters, and more than 350 global contributors.

   

• Includes chapters devoted to clinical correlation that help explain the implications of fetal and neonatal physiology, as well as clinical applications boxes throughout.

   

• Provides summary boxes at the end of each chapter and extensive cross-referencing between chapters for quick reference and review.

   

• Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more.

   

• Enhanced eBook version included with purchase.

   Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

   

Table Of Contents:

 

Volume 1

Section I Genetics and

1 Basic Genetic Principles, 1

2 Epigenetics, 11

3 Basic Embryology, 23

4 Regulation of Embryogenesis, 38

5 The Extracellular Matrix in Development, 47

6 Angiogenesis, 54

7 Prenatal Diagnosis, 58

Section II Placenta and

Intrauterine Environment

8 Placental Development, 67

9 Regulation of the Placental Circulation, 80

10 Mechanisms of Transfer Across the Human

Placenta, 89

11 Endocrine and Paracrine Function of the Human

Placenta, 101

Anna A.

Penn

12 Intra-Amniotic Infection/Inflammation and the

Fetal Inflammatory Response Syndrome, 111

13 Fetal Origins of Adult Disease: A Classic

14 Placental Function in Intrauterine Growth

Restriction, 137

Section III Developmental

Pharmacology

15 Basic Pharmacologic Principles, 150

16 Principles of Pharmacokinetics, 166

17 The Physiology of Placental Drug

Disposition, 173

18 Pharmacogenomics, 187

19 Drug Distribution in Fetal Life, 194

20 Drug Transfer During Breastfeeding, 203

Thomas W.

Hale | Kaytlin Krutsch

Section IV Intrauterine and

Postnatal Growth

21 Placental and Fetal Circulatory and Metabolic

Changes Accompanying Fetal Growth

Restriction, 214

22 Endocrine Factors Affecting Neonatal

Growth, 224

23 Human Milk Composition and Function in the

Infant, 241

24 Physiology of Lactation, 249

Section V Perinatal Iron, Mineral, and Vitamin Metabolism

25 Fetal and Neonatal Iron Metabolism, 257

26 Fetal and Neonatal Calcium, Phosphorus, and

Magnesium Homeostasis, 265

27 Zinc in the Fetus and Neonate, 282

28 Vitamin A Metabolism in the Fetus and Neonate, 287

29 Vitamin E Nutrition in Pregnancy and the

Newborn Infant, 295

30 Vitamin K Metabolism in the Fetus and

Neonate, 303

Section VI Lipid Metabolism

31 Maternal-Fetal Transfer of Lipid

Metabolites, 311

32 Brown Adipose Tissue: Development and

Function, 323

33 Lipids as an Energy Source for the Premature

and Term Neonate, 332

34 Ketone Body Metabolism in the Neonate, 339

35 Long-Chain Polyunsaturated Fatty Acids in

Neurodevelopment, 348

Section VII Carbohydrate

Metabolism

36 Glucose Metabolism in the Fetus and Newborn,

and Methods for Its Investigation, 358

37 Oxygen Consumption and General

Carbohydrate Metabolism of the Fetus, 368

38 Role of Glucoregulatory Hormones in Hepatic

Glucose Metabolism During the Perinatal

Period, 382

39 Cell Glucose Transport and Glucose Handling

During Fetal and Neonatal Development, 392

Section VIII Protein

Metabolism

40 General Concepts of Protein Metabolism, 400

41 Placental Transfer and Fetal Requirements of

Amino Acids, 408

Section IX

Thermoregulation

42 Temperature Control in Newborn Infants, 423

Section X Skin

43 Structure and Development of the Skin and

Cutaneous Appendages, 446

44 Physiologic Development of the Skin, 454

Section XI Fetal and Neonatal Cardiovascular Physiology

45 Cardiovascular Development, 473

46 Developmental Electrophysiology in the Fetus

and Neonate, 482

47 Developmental Biology of the Pulmonary

Vasculature, 501

48 Development of the Gastrointestinal Circulation

in the Fetus and Newborn, 517

49 Physiology of Congenital Heart Disease in the

Neonate, 521

50 Regulation of Cardiovascular Function During

Fetal and Newborn Life, 534

51 Nutritional and Environmental Effects on the

Fetal Circulation, 545

52 Mechanisms Regulating Closure of the Ductus

Arteriosus, 553

53 Umbilical Circulation, 564

54 Fetal and Placental Circulation During Labor, 576

Section XII The Lung

55 Normal and Abnormal Structural Development

of the Lung, 585

56 Regulation of Alveolarization, 600

57 Physiologic Mechanisms of Normal and Altered

Lung Growth Before and After Birth, 605

58 Molecular Mechanisms of Lung Development

and Lung Branching Morphogenesis, 617

59 Regulation of Liquid Secretion and Absorption

by the Fetal and Neonatal Lung, 626

60 Upper Airway Structure: Function, Regulation,

and Development, 635

61 Regulation of Lower Airway Function, 645

62 Functional Development of Respiratory Muscles, 652

63 Mechanics of Breathing, 665

64 Pulmonary Gas Exchange in the Developing Lung, 673

65 Oxygen Transport and Delivery, 684

66 Control of Breathing in Fetal Life and Onset and

Control of Breathing in the Neonate, 697

67 Basic Mechanisms of Oxygen Sensing and

Adaptation to Hypoxia, 707

68 Evaluation of Pulmonary Function in the

Neonate, 714

69 Mechanisms of Neonatal Lung Injury, 728

70 Impaired Lung Growth After Injury in Preterm

Lung, 734

71 Antenatal Factors That Influence Postnatal Lung

Development and Injury, 748

72 Regulation of Pulmonary Circulation, 757

SECTION XIII Surfactant

73 Historical Perspective, 765

74 Developmental Biology of Lung Stem Cells, 768

75 Surfactant Homeostasis: Composition and

Function of Pulmonary Surfactant Lipids and

Proteins, 776

76 Structure and Development of Alveolar

Epithelial Cells, 787

77 Regulation of Surfactant-Associated

Phospholipid Synthesis and Secretion, 792

78 Antenatal Hormonal Therapy for Prevention of

Respiratory Distress Syndrome, 804

79 Surfactant Treatment, 813

80 Genetics and Physiology of Surfactant Protein

Deficiencies, 825

SECTION XIV Physiology of Gastrointestinal Tract in the

Fetus and Neonate

81 Trophic Factors and Regulation of Gastrointestinal Tract and Liver

Development, 838

82.

Organogenesis of the Gastrointestinal Tract, 845

83 Development of Gastric Secretory Function, 854

84 Development of the Enteric Nervous System and

Gastrointestinal Motility, 859

85 Development of the Endocrine and Exocrine Pancreas, 868

86 Digestive-Absorptive Functions in Fetuses,

Infants, and Children, 881

87 The Developing Microbiome of the Fetus and

Neonate: A Multiomic Approach, 888

SECTION XV Liver and Bilirubin Metabolism

88 Organogenesis and Histologic Development of

the Liver, 896

89 Bile Acid Metabolism During Development, 901

90 Fetal and Neonatal Bilirubin Metabolism, 915

91 Hereditary Contributions to Neonatal

Hyperbilirubinemia, 919

92 Mechanistic Aspects of Phototherapy for

Neonatal Hyperbilirubinemia, 930

Volume 2

Section XVI The Kidney

93 Development of the Kidney: Morphology and

Mechanisms, 941

94 Functional Development of the Kidney in

Utero, 954

95 Development and Regulation of Renal Blood

Flow in the Neonate, 965

96 Postnatal Development of Glomerular Filtration

Rate in Neonates, 975

97 Renal Transport of Sodium During Development, 984

98 Potassium Homeostasis in the Fetus and

Neonate, 992

99 Role of the Kidney in Calcium and Phosphorus

Homeostasis, 1006

100 Transport of Amino Acids in the Fetus and

Neonate, 1018

101 Organic Anion Transport in the Developing

Kidney, 1024

102 Concentration and Dilution of Urine, 1030

103 Urinary Acidification, 1047

104 Response to Nephron Loss in Early

Development, 1056

SECTION XVII Fluid and

Electrolyte Metabolism

105 Fluid Distribution in the Fetus and Neonate, 1064

106 Regulation of Acid-Base Balance in the Fetus

and Neonate, 1076

Section XVIII Developmental Hematopoiesis

107 Developmental Biology of Hematopoietic Stem

Cells, 1082

108 Neutrophil Granulopoiesis and Homeostasis, 1093

109 Developmental Erythropoiesis, 1104

110 Developmental Megakaryopoiesis, 1125

Section XIX Hemostasis

111 Developmental Hemostasis, 1145

112 Platelet–Vessel Wall Interactions, 1153

Section XX Developmental Immunobiology

113 Host Defense Mechanisms Against Bacteria, 1158

114 Host Defense Mechanisms Against Fungi, 1167

115 Host Defense Mechanisms Against Viruses, 1172

116 T-Cell Development, 1195

117 B-Cell Development, 1200

118 Mononuclear Phagocyte System, 1206

119 Normal and Abnormal Neutrophil Physiology in

the Newborn, 1215

120 The Complement System of the Fetus and

Newborn, 1232

121 Cytokines and Inflammatory Response in the

Fetus and Neonate, 1243

122 Immunology of Human Milk, 1257

123 Neonatal Pulmonary Host Defense, 1265

Section XXI Neurology

124 Development of the Nervous System, 1297

125 Mechanisms of Cell Death in the Developing

Brain, 1318

126 Development of the Blood-Brain Barrier, 1327

127 Trophic Factor, Nutritional, and Hormonal

Regulation of Brain Development, 1341

David Pleasure

128 Developmental Aspects of Pain, 1347

129 Cerebellar Development—The Impact of Preterm

Birth and Comorbidities, 1353

130 Electroencephalography in the Preterm and

Term Infant, 1367

131 Intraventricular Hemorrhage in the

Neonate, 1394

132 Pathophysiology of Neonatal White Matter

Injury, 1414

133 Cellular and Molecular Mechanisms of Neonatal Brain Injury and

Neuroprotection, 1422

134 Neuroprotective Therapeutic Hypothermia, 1432

Section XXII Special Sensory Systems in the Fetus and

Neonate

135 Early Development of the Human Auditory System, 1440

136 Development of Olfaction and Taste in the

Human Fetus and Neonate, 1455

Section XXIII Musculoskeletal

137 The Growth Plate: Embryologic Origin,

Structure, and Function, 1465

138 Ontogenesis of Striated Muscle, 1475

Section XXIV Endocrine Function

139 Hypothalamus: Neuroendometabolic Center, 1495

140 Growth Factor Regulation of Fetal Growth, 1505

141 Growth Hormone, Prolactin, and Placental

Lactogen in the Fetus and Newborn, 1514

142 Luteinizing Hormone and Follicle-Stimulating

Hormone Secretion in the Fetus and Newborn Infant, 1520

143 Development of the Hypothalamus-Pituitary-

Adrenal Axis in the Fetus, 1532

144 Fetal and Neonatal Adrenocortical

Physiology, 1538

145 Fetal and Neonatal Thyroid Physiology, 1546

Section XXV Ovary and Testis

146 Genetics of Sex Determination and

Differentiation, 1555

147 Differentiation of the Ovary, 1566

148 Testicular Development and Descent, 1574

Section XXVi

PAT HOPHYSIOLOGY OF NEONATAL

DISEASES

149 The Pathophysiology of Twin-Twin Transfusion

Syndrome, Twin-Anemia Polycythemia Sequence,

and Twin-Reversed Arterial Perfusion, 1582

150 Physiology of Neonatal Resuscitation, 1589

151 Pathophysiology of Neonatal Sepsis, 1606

152 Pathophysiology of Neonatal

Hypoglycemia, 1624

153 Pathophysiology of Cardiomyopathies, 1633

154 Pathophysiology of Persistent Pulmonary

Hypertension of the Newborn, 1648

155 Pathophysiology of Shock in the Fetus and

Neonate, 1662

156 Pathophysiology of Apnea of

Prematurity, 1671

157 Pathophysiology of Respiratory Distress

Syndrome, 1680

158 Pathophysiology of Meconium Aspiration

Syndrome, 1696

159 Pathophysiology of Bronchopulmonary

Dysplasia, 1703

160 Pathophysiology of Ventilator-Dependent

Infants, 1710

161 Pathophysiology of Gastroesophageal

Reflux, 1722

162 Pathophysiology and Prevention of Neonatal

Necrotizing Enterocolitis, 1732

163 Pathophysiology of Kernicterus, 1738

164 Pathophysiology of Neonatal Acute Kidney

Injury, 1750

165 Pathophysiology of Edema, 1760

166 Pathophysiology of Retinopathy of

Prematurity, 1765

167 Pathophysiology of Neonatal Hypoxic-Ischemic

Brain Injury, 1773

168 Pathophysiology of Neonatal Acute Bacterial

Meningitis, 1784

169 Pathophysiology of Neural Tube

Defects, 1797

170 Pathophysiology of Preeclampsia, 1811

171 Pathophysiology of Preterm Birth, 1820

172 Pathophysiology of Chorioamnionitis: Host

Immunity and Microbial Virulence, 1828

173 Pathophysiology of Genetic Neonatal

Disease, 1837

174 Genetic Variants and Neonatal Disease, 1846