Kidney Transplantation, Bioengineering, and Regeneration, Kidney Transplantation in the Regenerative Medicine Era

Description:

Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement.

In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney.

• Focuses on the synergy between renal organ transplantation and regenerative medicine, highlighting the advances within transplantation, bioengineering, regeneration, and repair
• Educates the transplant community on important regenerative medicine research pertinent to kidney transplantation
• Develops a shared language for clinicians, surgeons, and basic researchers to reach across the fields of transplantation and regenerative medicine, and facilitate more productive investigation and research
• Catalogs the technologies being developed and methods being implemented to bioengineer or regenerate kidneys to restore function

· Introduction

· Part I: Kidney Transplantation

· Section I: Epidemiology of Kidney Disease and Transplantation

· Chapter

1. Epidemiology of End-Stage Renal Failure: The Burden of Kidney Diseases to Global Health

· Chapter

2. Transplant Programs Worldwide and the Spanish Miracle

· Section II: Donor Selection and Allocation

· Chapter

3. The Deceased Kidney Donor

· Chapter

4. The Living Donor

· Chapter

5. Criteria for Kidney Allocation in the United States

· Chapter

6. Strategies to Increase the Donor Pool

· Section III: Kidney Preservation and Transplant Procedures

· Chapter

7. Kidney Preservation

· Chapter

8. Ex-vivo Normothermic Perfusion in Renal Transplantation

· Chapter

9. Kidney Transplant Recipient Surgery

· Chapter

10. Robotic-Assisted Kidney Transplantation

· Chapter

11. Orthotopic Kidney Transplantation

· Chapter

12. Kidney Transplantation Combined With Other Organs

· Chapter

13. Pediatric Renal Transplantation

· Section IV: Kidney Recipient: Before and Peritransplant

· Chapter

14. Indications for Renal Transplantation: Evaluation of Transplant Candidates

· Abstract

· Chapter

15. Early Postoperative ICU Care of the Kidney Transplant Recipient

· Chapter

16. Approaches to Minimize Delayed Graft Function in Renal Transplantation

· Section V: Transplantation Immunology and Immunomodulation

· Chapter

17. Histocompatibility Testing in the Transplant Setting

· Chapter

18. The Immune Response to the Allograft

· Chapter

19. Induction Immunosuppression in Kidney Transplantation

· Chapter

20. Maintenance Immunosuppression in Kidney Transplantation

· Chapter

21. Novel Drugs in Kidney Transplantation

· Chapter

22. Hematopoietic Stem Cell Transplantation for Induction of Allograft Tolerance

· Chapter

23. Regulatory T Cell Therapy in Transplantation

· Chapter

24. Mesenchymal Stromal Cells to Improve Solid Organ Transplant Outcome:

· Chapter

25. Renal Transplantation Across HLA and ABO Barriers

· Section VI: Graft Monitoring Tools

· Chapter

26. Pathology of the Renal Allograft

· Chapter

27. Imaging-Based Monitoring of the Renal Graft

· Chapter

28. Immune Monitoring in Kidney Transplantation

· Chapter

29. Renal Function Measurements

· Chapter

30. Pharmacokinetics and Genomics of Immunosuppressive Drugs

· Chapter

31. Gene Expression Technology Applied to Kidney Transplantation

· Section VII: Early Posttransplant Immune Events

· Chapter

32. Acute Cellular Rejection

· Chapter

33. Acute Antibody-Mediated Rejection

· Section VIII: Early and Late Complications

· Chapter

34. Vascular Complications in Renal Transplantation

· Chapter

35. Infections in Kidney Transplant Recipients

· Chapter

36. Metabolic Disorders Following Kidney Transplantation

· Chapter

37. Cancer After Kidney Transplantation

· Chapter

38. Cardiovascular Disease and Renal Transplantation

· Chapter

39. Graft and Patient Survival

· Chapter

40. Urological Complications of the Renal Graft

· Chapter

41. Impact of De Novo Donor-specific Alloantibody in Primary Renal Allografts

· Chapter

42. De Novo and Recurrence of Renal Disease

· Section X: Transplant Issues in Specific Patient Groups

· Chapter

43. Kidney Transplantation in the Elderly

· Chapter

44. Dual Kidney Transplantation

· Chapter

45. Kidney Transplantation in the Diabetic Patient

· Chapter

46. Kidney Transplantation in the Hepatitis C Infected Recipient

· Chapter

47. Pregnancy After Kidney Transplantation

· Chapter

48. Nutrition of the Kidney Transplant Recipients

· Section XI: Ethics and Costs

· Chapter

49. Kidney Transplantation in Developing Countries

· Chapter

50. Health-Related Quality of Life Outcomes After Kidney Transplantation

· Chapter

51. Costs of Kidney Transplantation

· Section XII: Unmet Needs

· Chapter

52. Kidney Transplantation: Have the Promises Been Kept and Needs Met

· Chapter

53. Innovations in Kidney Transplant Research

· Part II: Kidney Bioengineering and Regeneration

· Section I: Introduction

· Chapter

54. Converging Organ Transplantation Towards Regenerative Medicine

· Chapter

55. A Systems Engineering Approach to Restoring Kidney Structure and Function

· Abstract

· Section II: Kidney Development

· Chapter

56. Kidney Development in the Mammal

· Chapter

57. Renal Branching Morphogenesis

· Section III: Bioengineering

· Chapter

58. Principles of Stem Cell Biology Applied to the Kidney

· Chapter

59. Extracellular Matrix Biology Applied to the Kidney

· Chapter

60. Interplay Between Growth Factor Receptors, Small GTPases, and Mechanical Stress in the Maintenance of Kidney Glomerular Homeostasis

· Chapter

61. Bioengineering Approach to Immunomodulation

· Chapter

62. Principles of Organ Bioengineering

· Chapter

63. Recellularization of Kidney Scaffold With Stem Cells

· Section IV: Bioreactors and Biomaterials

· Chapter

64. Bioreactors for Cell Culture Systems and Organ Bioengineering

· Chapter

65. Synthetic Biomaterial for Regenerative Medicine Applications

· Chapter

66. Immune Responses to Biomaterials Used in Renal Engineering

· Section V: Regeneration

· Chapter

67. Regeneration of Kidney From Human Reprogrammed Stem Cells

· Chapter

68. Bioprinting Complex 3D Tissue and Organs

· Chapter

69. Principles of Kidney Regeneration

· Chapter

70. Markers of Repair and Regeneration in the Marginal Kidney

· Chapter

71. Nephron Repair in Mammals and Fish

· Chapter

72. Imaging of Glomerular Regeneration

· Chapter

73. Reversibility of Renal Fibrosis

· Chapter

74. Pharmacological Induction of Kidney Regeneration

· Chapter

75. Developmental Approaches to Kidney Regeneration

· Section VI: Adult Cells for Regeneration

· Chapter

76. Nephron Progenitors

· Chapter

77. Urine Progenitor Cells for Potential Application in Renal Tissue Repair

· Chapter

78. Endothelial Progenitor Cells in Kidney Disease

· Section VII: Cell Therapy For Renal Tissue Repair

· Chapter

79. Mesenchymal Stromal Cells for Acute Renal Injury

· Chapter

80. Amniotic Fluid Cells: Kidney Injury and Regeneration

· Chapter

81. Renal Cells From Spermatogonial Germline Stem Cells for Protection Against Kidney Injury

· Chapter

82. Kidney-on-a-Chip: Technologies for Studying Pharmacological and Therapeutic Approaches to Kidney Repair

· Chapter

83. Renal Replacement Devices

· Chapter

84. Xenotransplantation and Kidney Regenerative Technology

· Chapter

85. Embryonic Organoid Transplantation

· Chapter

86. Lineage Reprogramming Toward Kidney Regeneration

· Chapter

87. Regenerating Kidney Structure and Function: An Industry Perspective